Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages.
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作者：
我们评估了不同小鼠器官中的组织巨噬细胞基因表达。不同巨噬细胞群体之间基因表达的多样性是显着的。只有几百个mRNA转录物被巨噬细胞选择性表达而不是DC，其中许多并不存在于所有巨噬细胞中。尽管如此，充分表征的表面标志物，包括MerTK和FcγR1（CD 64），沿着一簇新转录物，与成熟组织巨噬细胞明显且普遍相关。TCEF 3、C/EBPα、BACH 1和CREG-1是预测调节这些核心巨噬细胞相关基因的顶级转录调节因子。其他转录因子mRNA与单个巨噬细胞群体密切相关。我们进一步说明了这些转录本和它们编码的蛋白质如何促进区分巨噬细胞与DC身份的单核吞噬细胞的特征较少的群体。
We assessed tissue macrophage gene expression in different mouse organs. Diversity in gene expression among different populations of macrophages was remarkable. Only a few hundred mRNA transcripts stood out as selectively expressed by macrophages over DCs and many of these were not present in all macrophages. Nonetheless, well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of novel transcripts were distinctly and universally associated with mature tissue macrophages. TCEF3, C/EBPα, BACH1, and CREG-1 were among the top transcriptional regulators predicted to regulate these core macrophage-associated genes. Other transcription factor mRNAs were strongly associated with single macrophage populations. We further illustrate how these transcripts and the proteins they encode facilitate distinguishing macrophage versus DC identity of less characterized populations of mononuclear phagocytes.
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影响因子：
4.3
作者：
Moolmuang, Benchamart;Tainsky, Michael A.
通讯作者：
Tainsky, Michael A.
DOI：
10.1084/jem.20101709
发表时间：
2011-05-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hashimoto D;Chow A;Greter M;Saenger Y;Kwan WH;Leboeuf M;Ginhoux F;Ochando JC;Kunisaki Y;van Rooijen N;Liu C;Teshima T;Heeger PS;Stanley ER;Frenette PS;Merad M
通讯作者：
Merad M
DOI：
10.1126/science.1170540
发表时间：
2009-04-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Liu K;Victora GD;Schwickert TA;Guermonprez P;Meredith MM;Yao K;Chu FF;Randolph GJ;Rudensky AY;Nussenzweig M
通讯作者：
Nussenzweig M
影响因子：
56.9
作者：
Fogg, DK;Sibon, C;Geissmann, F
通讯作者：
Geissmann, F
影响因子：
15.3
作者：
Ginhoux, Florent;Collin, Matthew P;Bogunovic, Milena;Abel, Michal;Leboeuf, Marylene;Helft, Julie;Ochando, Jordi;Kissenpfennig, Adrien;Malissen, Bernard;Grisotto, Marcos;Snoeck, Hans;Randolph, Gwendalyn;Merad, Miriam
通讯作者：
Merad, Miriam