Emerging point-of-care technologies for sickle cell disease screening and monitoring.
Emerging point-of-care technologies for sickle cell disease screening and monitoring.
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DOI：
10.1080/17434440.2016.1254038
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发表时间：
2016-12
影响因子：
3.1
通讯作者：
Gurkan UA
中科院分区：
文献类型：
--
作者：
Alapan Y;Fraiwan A;Kucukal E;Hasan MN;Ung R;Kim M;Odame I;Little JA;Gurkan UA
镰状细胞病（SCD）影响着10万美国人和全球1400多万人，其中大部分是经济弱势群体，需要在出生后进行早期诊断，并在患者的整个生命周期中进行持续监测。在发展中国家，由于对熟练人员的需求和目前可用模式的高成本，SCD的早期诊断仍然是预防儿童死亡的挑战。另一方面，由于患者群体之间以及同一个体纵向的异质性，SCD监测提出了难以克服的挑战。在这里，我们描述了用于SCD筛查和监测的新兴的护理点微/纳米平台技术，并批判性地讨论了当前最先进的技术，与这些技术相关的潜在挑战以及未来的发展方向。最近开发的微技术提供了简单，快速和负担得起的SCD筛查，并有可能促进资源有限的环境和发展中国家的普遍筛查。另一方面，SCD的监测比诊断更复杂，需要全面验证疗效。在新兴疗法的新临床试验设计中，早期使用新型微型设备进行患者监测可能会特别方便。
Sickle Cell Disease (SCD) affects 100,000 Americans and more than 14 million people globally, mostly in economically disadvantaged populations, requires early diagnosis after birth and constant monitoring throughout the life-span of the patient. Early diagnosis of SCD still remains a challenge in preventing childhood mortality in the developing world due to requirements of skilled personnel and high-cost of currently available modalities. On the other hand, SCD monitoring presents insurmountable challenges due to heterogeneities among patient populations, as well as in the same individual longitudinally. Here, we describe emerging point-of-care micro/nano platform technologies for SCD screening and monitoring, and critically discuss current state-of-the-art, potential challenges associated with these technologies, and future directions. Recently developed microtechnologies offer simple, rapid, and affordable screening of SCD and have the potential to facilitate universal screening in resource-limited settings and developing countries. On the other hand, monitoring of SCD is more complicated compared to diagnosis and requires comprehensive validation of efficacy. Early use of novel microdevices for patient monitoring might come in especially handy in new clinical trial designs of emerging therapies.
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影响因子：
6.5
作者：
Ataga, Kenneth I.;Reid, Marvin;Stocker, Jonathan W.
通讯作者：
Stocker, Jonathan W.
影响因子：
20.3
作者：
BALLAS, SK;SMITH, ED
通讯作者：
SMITH, ED
DOI：
10.1016/j.trsl.2016.03.008
发表时间：
2016-07
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
Alapan Y;Kim C;Adhikari A;Gray KE;Gurkan-Cavusoglu E;Little JA;Gurkan UA
通讯作者：
Gurkan UA
DOI：
10.4084/mjhid.2013.062
发表时间：
2013
影响因子：
3.2
作者：
Ansong D;Akoto AO;Ocloo D;Ohene-Frempong K
通讯作者：
Ohene-Frempong K
DOI：
10.1016/s0197-2456(97)00099-8
发表时间：
1998-02-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Adams, RJ;McKie, VC;Waclawiw, MA
通讯作者：
Waclawiw, MA