Cohort profile: Study of Transition, Outcomes and Gender (STRONG) to assess health status of transgender people.
Cohort profile: Study of Transition, Outcomes and Gender (STRONG) to assess health status of transgender people.
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DOI：
10.1136/bmjopen-2017-018121
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发表时间：
2017-12-27
期刊：
影响因子：
2.9
通讯作者：
Goodman M
中科院分区：
文献类型：
--
作者：
Quinn VP;Nash R;Hunkeler E;Contreras R;Cromwell L;Becerra-Culqui TA;Getahun D;Giammattei S;Lash TL;Millman A;Robinson B;Roblin D;Silverberg MJ;Slovis J;Tangpricha V;Tolsma D;Valentine C;Ward K;Winter S;Goodman M
在佐治亚州、北加州和南加州的Kaiser Permanente健康计划中，启动了关于过渡、结果和性别的研究(STRONG)，以评估变性人的一般健康状况和在接受性别肯定治疗后的健康状况。这一通报的目的是描述队列确定和数据收集的方法，并描述研究人群的特征。采用计算机搜索电子医疗记录和自由文本验证资格和性别认同的逐步方法，确定了在2006年至2014年期间首次有变性人身份证据的6456名成员。队列包括3475名(54%)变性女性(TF)，2892名(45%)变性男性(TM)和89名(1%)出生性别和性别认同未从记录中确定的成员。队列与127名没有变性证据的 608参与者(63名 825名女性和63名 783名男性)在出生年份、种族/民族、学习地点和成员年份进行了匹配。队列后续行动将持续到2016年底。约58%的TF和52%的TM队列成员在Kaiser Permanente接受了激素治疗。胸部手术在TM参与者中更为常见(12%对0.3%)。在两组变性人中，接受生殖器重建手术的变性人比例相似(4%-5%)。结果表明，在TF和TM队列中有足够数量的事件来进一步检查精神健康状况、心血管事件、糖尿病、艾滋病毒和最常见的癌症。STRONG有能力通过对变性人和参考人群的比较以及对性别肯定治疗前后健康状况的分析，填补现有的知识空白。分析将包括心血管疾病、精神健康、艾滋病毒和糖尿病的发病率，以及以实验室为基础的终点的变化(例如，红细胞增多症和骨密度)，总体上以及与性别肯定疗法有关的变化。
The Study of Transition, Outcomes and Gender (STRONG) was initiated to assess the health status of transgender people in general and following gender-affirming treatments at Kaiser Permanente health plans in Georgia, Northern California and Southern California. The objectives of this communication are to describe methods of cohort ascertainment and data collection and to characterise the study population. A stepwise methodology involving computerised searches of electronic medical records and free-text validation of eligibility and gender identity was used to identify a cohort of 6456 members with first evidence of transgender status (index date) between 2006 and 2014. The cohort included 3475 (54%) transfeminine (TF), 2892 (45%) transmasculine (TM) and 89 (1%) members whose natal sex and gender identity remained undetermined from the records. The cohort was matched to 127 608 enrollees with no transgender evidence (63 825 women and 63 783 men) on year of birth, race/ethnicity, study site and membership year of the index date. Cohort follow-up extends through the end of 2016. About 58% of TF and 52% of TM cohort members received hormonal therapy at Kaiser Permanente. Chest surgery was more common among TM participants (12% vs 0.3%). The proportions of transgender participants who underwent genital reconstruction surgeries were similar (4%–5%) in the two transgender groups. Results indicate that there are sufficient numbers of events in the TF and TM cohorts to further examine mental health status, cardiovascular events, diabetes, HIV and most common cancers. STRONG is well positioned to fill existing knowledge gaps through comparisons of transgender and reference populations and through analyses of health status before and after gender affirmation treatment. Analyses will include incidence of cardiovascular disease, mental health, HIV and diabetes, as well as changes in laboratory-based endpoints (eg, polycythemia and bone density), overall and in relation to gender affirmation therapy.
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影响因子：
3.8
作者：
Giami, Alain;Beaubatie, Emmanuelle
通讯作者：
Beaubatie, Emmanuelle
影响因子：
3.9
作者：
Brown, George R.;Jones, Kenneth T.
通讯作者：
Jones, Kenneth T.
影响因子：
3.7
作者：
Dhejne, Cecilia;Lichtenstein, Paul;Landen, Mikael
通讯作者：
Landen, Mikael
DOI：
10.1161/circoutcomes.108.801654
发表时间：
2008-11-01
影响因子：
6.9
作者：
Go, Alan S.;Magid, David J.;Gurwitz, Jerry H.
通讯作者：
Gurwitz, Jerry H.
影响因子：
7.8
作者：
Kreukels, B. P. C.;Haraldsen, I. R.;Cohen-Kettenis, P. T.
通讯作者：
Cohen-Kettenis, P. T.