A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses.

A unique host defense pathway: TRIF mediates both antiviral and antibacterial immune responses.
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DOI:
10.1016/j.micinf.2012.10.011
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发表时间:
2013-01
影响因子:
5.8
通讯作者:
Fukata M
Fukata M
中科院分区:
医学3区
文献类型:
--
作者:
Hyun J;Kanagavelu S;Fukata M

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Both anti-viral and anti-bacterial host defense mechanisms involve TRIF signaling. TRIF provides early clearance of pathogens and coordination of a local inflammatory ensemble through an interferon cascade, while it may trigger organ damage. The multipotentiality of TRIF-mediated immune machinery may direct the fate of our continuous battle with microbes.
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