Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
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DOI：
10.1371/journal.pone.0005990
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发表时间：
2009-06-22
期刊：
影响因子：
3.7
通讯作者：
Hooton TM
中科院分区：
文献类型：
--
作者：
Hawn TR;Scholes D;Li SS;Wang H;Yang Y;Roberts PL;Stapleton AE;Janer M;Aderem A;Stamm WE;Zhao LP;Hooton TM
虽然行为风险因素与尿路感染（UTI）风险密切相关，但遗传学在获得这种疾病中的作用知之甚少。为了验证Toll样受体（TLR）通路基因多态性与尿路感染易感性相关的假设，我们对18-49岁的女性进行了一项基于人群的病例对照研究。我们检测了431例复发性膀胱炎（鲁蒂）病例、400例肾盂肾炎病例和430例无UTI病史的对照组中9个TLR通路基因的DNA变异。在987名白人女性亚组中，多态性TLR4_A896G与鲁蒂保护相关，但与肾盂肾炎无关，比值比（OR）为0.54，95%置信区间（CI）为0.31至0.96。TLR5_C1174T多态性编码一种消除鞭毛蛋白诱导信号的变体，与鲁蒂风险增加相关（OR（95%CI）：1.81（1.00-3.08）），但与肾盂肾炎无关。TLR1_G1805T多态性与肾盂肾炎保护相关（OR（95%CI）：0.53（0.29-0.96））。这些结果提供了TLR 5和TLR 1变异体分别与获得鲁蒂和肾盂肾炎的风险改变相关的第一个证据。尽管这些数据表明TLR多态性与成人尿路感染易感性相关，但统计学意义不大，需要进一步研究，包括独立队列的验证。
Although behavioral risk factors are strongly associated with urinary tract infection (UTI) risk, the role of genetics in acquiring this disease is poorly understood. To test the hypothesis that polymorphisms in Toll-like receptor (TLR) pathway genes are associated with susceptibility to UTIs, we conducted a population-based case-control study of women ages 18–49 years. We examined DNA variants in 9 TLR pathway genes in 431 recurrent cystitis (rUTI) cases, 400 pyelonephritis cases, and 430 controls with no history of UTIs. In the Caucasian subgroup of 987 women, polymorphism TLR4_A896G was associated with protection from rUTI, but not pyelonephritis, with an odds ratio (OR) of 0.54 and a 95% confidence interval (CI) of 0.31 to 0.96. Polymorphism TLR5_C1174T, which encodes a variant that abrogates flagellin-induced signaling, was associated with an increased risk of rUTI (OR(95%CI): 1.81 (1.00–3.08)), but not pyelonephritis. Polymorphism TLR1_G1805T was associated with protection from pyelonephritis (OR(95%CI): 0.53 (0.29–0.96)). These results provide the first evidence of associations of TLR5 and TLR1 variants with altered risks of acquiring rUTI and pyelonephritis, respectively. Although these data suggest that TLR polymorphisms are associated with adult susceptibility to UTIs, the statistical significance was modest and will require further study including validation with independent cohorts.
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一种常见的主导TLR5停止密码子多态性废除了鞭毛蛋白信号传导，并与对军团疾病的易感性有关。
影响因子：
15.3
作者：
Hawn, TR;Verbon, A;Lettinga, KD;Zhao, LP;Li, SS;Laws, RJ;Skerrett, SJ;Beutler, B;Schroeder, L;Nachman, A;Ozinsky, A;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
--
作者：
Jerde, TJ;Bjorling, DE;Saban, R
通讯作者：
Saban, R
影响因子：
3.6
作者：
Karoly, Eva;Fekete, Andrea;Reusz, Georg S.
通讯作者：
Reusz, Georg S.
影响因子：
2.1
作者：
Liu, ZQ;Lin, SL
通讯作者：
Lin, SL
影响因子：
105.7
作者：
KINANE, DF;BLACKWELL, CC;ELTON, RA
通讯作者：
ELTON, RA