Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling.
Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling.
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DOI：
10.1016/j.medengphy.2011.05.008
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发表时间：
2011-12
影响因子：
2.2
通讯作者：
Koenig SC
中科院分区：
文献类型：
--
作者：
Giridharan GA;Lederer C;Berthe A;Goubergrits L;Hutzenlaub J;Slaughter MS;Dowling RD;Spence PA;Koenig SC
历史上，单端口无阀气动血泵由于血液停滞区域和由于高剪切应力区域引起的溶血而具有血栓形成的高发生率。为了确保最小的溶血和良好的血液冲洗特性，粒子图像测速（PIV）和计算流体动力学（CFD）被用来评估一个新的单端口，无阀反搏装置（交响乐）的设计。在小牛模型（Jersey，76 kg）的6小时急性（n=8）、5天（n=8）和30天（n=2）慢性实验中测试Symphony设计。在急性（每小时）和慢性（每周）时间过程中收集静脉血样，以分析生化标志物的时间变化并定量血浆游离血红蛋白。研究结束时，对动物实施安乐死，并检查Symphony和终末器官（脑、肝、肾、肺、心脏和脾）的血栓形成。PIV和CFD均显示在充盈阶段形成了强烈的移动涡流，并且在排出阶段血液从Symphony的所有区域均匀流出。在整个充盈和排出阶段，通过CFD估计的层流剪切应力仍远低于Symphony内400 Pa的溶血阈值。未观察到持续性血液停滞或血流分离区域。在急性和慢性实验中，每只试验动物在所有测量时间点的最大血浆游离血红蛋白（< 10 mg/dl）、平均血小板计数（植入前= 473 ± 56 K/μ L，植入后= 331 ± 62 K/μ L）和平均红细胞压积（植入前= 31 ± 2%，植入后= 29 ± 2%）均正常。肝功能（ALP、ALT）或肾功能（肌酐）测量值与Symphony植入前值相比无变化。尸检显示Symphony或终末器官中无血栓形成迹象。这些数据表明，设计的Symphony具有良好的清洗特性，在整个泵循环期间没有持续的血液停滞部位区域，并且溶血和血栓形成的风险较低。
Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. To ensure minimal hemolysis and favorable blood washing characteristics, Particle Image Velocimetry (PIV) and Computational Fluid Dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-hour acute (n=8), 5-day (n=8) and 30-day (n=2) chronic experiments in a calf model (Jersey, 76 kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Both the PIV and CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400 Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (< 10 mg/dl), average platelet count (pre-implant = 473 ± 56 K/μL and post-implant = 331 ± 62 K/μL), and average hematocrit (pre-implant = 31 ± 2 % and post-implant = 29 ± 2 %) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites during the entire pump cycle, and has a low risk of hemolysis and thrombus formations.
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影响因子：
4.2
作者：
Giridharan, GA;Pantalos, GM;Koenig, SC
通讯作者：
Koenig, SC
DOI：
10.1097/mat.0b013e318186891f
发表时间：
2008-11
期刊：
ASAIO journal (American Society for Artificial Internal Organs : 1992)
影响因子：
--
作者：
Koenig SC;Litwak KN;Giridharan GA;Pantalos GM;Dowling RD;Prabhu SD;Slaughter MS;Sobieski MA;Spence PA
通讯作者：
Spence PA
影响因子：
158.5
作者：
Rose, EA;Gelijns, AC;Meier, P
通讯作者：
Meier, P
影响因子：
2.4
作者：
Paul, R;Apel, J;Reul, H
通讯作者：
Reul, H
影响因子：
2.4
作者：
Doyle, Matthew G.;Vergniaud, Jean-Baptiste;Bourgault, Yves
通讯作者：
Bourgault, Yves