Prescribing practices of inhaled corticosteroids for premature infants in the neonatal intensive care unit.
Prescribing practices of inhaled corticosteroids for premature infants in the neonatal intensive care unit.
复制标题
新生儿重症监护室早产儿吸入皮质类固醇的处方实践。
DOI：
10.1038/s41372-024-01891-w
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Lang,JasonE
中科院分区：
文献类型：
--
作者：
Tang,Monica;Ibrahim,Anna;Laughon,Christopher;Moore,Kaila;Tejada,Angibel;Tran,Dean;Kilpatrick,Ryan;Greenberg,RachelG;Hornik,ChristophP;Zimmerman,Kanecia;Laughon,MatthewM;Clark,ReeseH;Lang,JasonE
目的尽管安全性和有效性数据有限，但吸入性皮质类固醇 (ICS) 仍被用于新生儿重症监护病房 (NICU) 的早产儿。我们检查了 NICU 中 ICS 使用的当代使用情况和风险因素。研究设计包括 2010 年至 2020 年间从 Pediatrix Medical Group NICU 出院的胎龄 <33 周和出生体重 <1500 克的婴儿。我们使用单变量和多变量逻辑回归评估了 ICS 处方与临床特征之间的关联。结果 在 308 个 NICU 的 74,123 名婴儿中，9253 名 (12.5%) 接受了 ICS 处方：布地奈德、氟替卡松或倍氯米松。支气管肺发育不良 (BPD) 的诊断、孕龄较早、男性、机械通气时间较长、氧支持和全身类固醇是 ICS 处方的独立危险因素。结论 ICS 的使用在许多 NICU 中很常见，并且与 BPD 的诊断和医疗保健利用相关。需要进行前瞻性试验来确定该弱势群体的安全性、有效性和最佳适应症。
ObjectiveDespite limited safety and efficacy data, inhaled corticosteroids (ICS) are prescribed to premature infants in the neonatal intensive care unit (NICU). We examined contemporary use and risk factors for ICS use in the NICU.Study designInfants <33 weeks gestational age and <1500 gm birth weight discharged from Pediatrix Medical Group NICUs between 2010 and 2020 were included. We evaluated the association between ICS prescription and clinical characteristics using univariable and multivariable logistic regression.ResultsOf 74,123 infants from 308 NICUs, 9253 (12.5%) were prescribed ICS: budesonide, fluticasone, or beclomethasone. Diagnosis of bronchopulmonary dysplasia (BPD), earlier gestational age, male sex, longer mechanical ventilation, oxygen support, and systemic steroids were independent risk factors for ICS prescription.ConclusionsUse of ICS is common in many NICUs and is associated with a diagnosis of BPD and healthcare utilization. Prospective trials are needed to establish the safety, efficacy, and optimal indication in this vulnerable population.
影响因子：
1.9
作者：
Zysman-Colman, Zofia;Tremblay, Genevieve M.;Landry, Jennifer S.
通讯作者：
Landry, Jennifer S.
对 223 个德国新生儿病房使用吸入类固醇的实践调查
影响因子：
2.5
作者：
Christoph Maas;Christian F. Poets;Dirk Bassler
通讯作者：
Dirk Bassler
产后皮质类固醇的使用
影响因子：
3.6
作者：
O. Williams;A. Greenough
通讯作者：
A. Greenough