Future Directions of Intraoperative Radiation Therapy: A Brief Review.

Future Directions of Intraoperative Radiation Therapy: A Brief Review.
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DOI:
10.3389/fonc.2017.00300
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发表时间:
2017
影响因子:
4.7
通讯作者:
Woloschak GE
Woloschak GE
中科院分区:
医学3区
文献类型:
--
作者:
Paunesku T;Woloschak GE

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术中放射治疗(IORT)的使用随着用于患者治疗的新器械的开发而增加,这些新器械允许在不需要将患者从手术台上移开的情况下进行照射。目前,IORT过程中的电离辐射最常通过使用产生电子的移动的设备、千伏X射线和电子近距离放射治疗以及开发适合于输送放射性核素进行短期近距离放射治疗的施源器来支持。建立未来可以预见的新的治疗设备和方案,例如,适合于IORT的质子或重离子源的开发或新治疗方案的建立,例如IORT与免疫系统调节剂或放射增敏纳米颗粒的组合使用,可能导致未来IORT的使用显著增加。这篇综述讨论了在这个时间点上仍然有限的使用IORT,并对未来可能的放射治疗方法提出了假设。
The use of intraoperative radiation therapy (IORT) is increasing with the development of new devices for patient treatment that allow irradiation without the need to move the patient from the surgical table. At the moment, ionizing radiation in the course of IORT is supported most often by the use of mobile devices that produce electrons, kilo voltage X-rays, and electronic brachytherapy and the development of applicators suitable for delivery of radionuclides for short-term brachytherapy. The establishment of new treatment devices and protocols that can be foreseen in the future, e.g., the development of proton or heavy ion sources suitable for IORT or the establishment of new treatment protocols such as the use of IORT in combination with immune system modulators or radiosensitizing nanoparticles, could lead to a significant increase in the use of IORT in the future. This review discusses the still limited use of IORT at this point in time and hypothesizes about possible future approaches to radiotherapy.
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