Prostatic fibrosis is associated with lower urinary tract symptoms.
Prostatic fibrosis is associated with lower urinary tract symptoms.
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DOI：
10.1016/j.juro.2012.06.007
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发表时间：
2012-10
影响因子：
6.6
通讯作者：
Macoska, Jill A.
中科院分区：
文献类型：
--
作者：
Ma, Jinjin;Gharaee-Kermani, Mehrnaz;Kunju, Lakshmi;Hollingsworth, John M.;Adler, Jeremy;Arruda, Ellen M.;Macoska, Jill A.
目前对继发于前列腺肥大的男性下尿路症状的治疗可防止激素对前列腺生长的影响，并抑制平滑肌收缩以缓解膀胱颈和尿道压力。然而，下尿路症状可能对这些疗法难以治疗，这表明它们未解决的其他生物过程也可能导致下尿路症状。衰老相关的组织结构纤维化变化导致多器官系统功能障碍。因此，我们测试了这种变化是否可能在尿道功能受损和男性下尿路症状中起作用。尿道周围组织从离体的整个前列腺和28个连续的根治性前列腺切除术治疗的男性。采用美国泌尿外科协会症状指数评估下尿路症状。对前列腺组织进行机械测试，以评估刚度和硬度。评价这些组织的固定切片的胶原蛋白和弹性蛋白含量以及腺体度以评估纤维化。统计分析包括学生t检验和计算Pearson相关系数以比较组。尿道周围前列腺组织表现出非线性粘弹性力学行为。与无下尿路症状的男性相比，有下尿路症状的男性的组织明显更硬（p = 0.0016），胶原蛋白含量明显更高（p = 0.0038），腺体含量更低（美国泌尿外科协会症状指数8或更高vs 7或更低）。研究结果表明，细胞外基质沉积和纤维化的特点，尿道周围前列腺组织的一些男性下尿路症状。他们指出纤维化是导致下尿路症状病因的一个因素。
Current therapies for male lower urinary tract symptoms secondary to prostate enlargement prevent hormonal effects on prostate growth and inhibit smooth muscle contraction to ease bladder neck and urethral pressure. However, lower urinary tract symptoms can be refractory to these therapies, suggesting that additional biological processes not addressed by them may also contribute to lower urinary tract symptoms. Aging associated fibrotic changes in tissue architecture contribute to dysfunction in multiple organ systems. Thus, we tested whether such changes potentially have a role in impaired urethral function and perhaps in male lower urinary tract symptoms. Periurethral tissues were obtained from a whole prostate ex vivo and from 28 consecutive men treated with radical prostatectomy. Lower urinary tract symptoms were assessed using the American Urological Association symptom index. Prostate tissues were subjected to mechanical testing to assess rigidity and stiffness. Fixed sections of these tissues were evaluated for collagen and elastin content, and glandularity to assess fibrosis. Statistical analysis included the Student t test and calculation of Pearson correlation coefficients to compare groups. Periurethral prostate tissues demonstrated nonlinear viscoelastic mechanical behavior. Tissue from men with lower urinary tract symptoms was significantly stiffer (p = 0.0016) with significantly higher collagen content (p = 0.0038) and lower glandularity than that from men without lower urinary tract symptoms (American Urological Association symptom index 8 or greater vs 7 or less). Findings show that extracellular matrix deposition and fibrosis characterize the periurethral prostate tissue of some men with lower urinary tract symptoms. They point to fibrosis as a factor contributing to lower urinary tract symptom etiology.
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影响因子：
2.4
作者：
LANIR, Y;FUNG, YC
通讯作者：
FUNG, YC
影响因子：
2.4
作者：
LANIR, Y;FUNG, YC
通讯作者：
FUNG, YC
影响因子：
--
作者：
Larkin, Lisa M.;Calve, Sarah;Arruda, Ellen M.
通讯作者：
Arruda, Ellen M.
DOI：
10.1016/j.ijantimicag.2007.08.028
发表时间：
2008-02-01
影响因子：
10.8
作者：
Krieger, John N.;Lee, Shaun Wen Huey;Riley, Donald E.
通讯作者：
Riley, Donald E.
DOI：
10.1016/j.biocel.2009.03.010
发表时间：
2009-11-01
影响因子：
4
作者：
Novo, Erica;di Bonzo, Lorenzo Valfre;Parola, Maurizio
通讯作者：
Parola, Maurizio