Identifying multiple change points in a linear mixed effects model.

Identifying multiple change points in a linear mixed effects model.
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DOI:
10.1002/sim.5996
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发表时间:
2014-03-15
影响因子:
2
通讯作者:
Albert, Paul S.
Albert, Paul S.
中科院分区:
医学3区
文献类型:
--
作者:
Lai, Yinglei;Albert, Paul S.

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虽然已经开发了纵向数据的变点分析方法,但通常感兴趣的是检测纵向数据中的多个变点。在本文中,我们提出了一个线性混合效应建模框架,用于识别纵向高斯数据中的多个变点。具体来说,我们开发了一种新的统计和计算框架,集成了期望最大化(EM)和动态规划(DP)算法。我们进行了全面的模拟研究,以证明我们的方法的性能。我们的方法是说明了从一项试验的数据分析,评估行为干预控制青少年I型糖尿病与HbA1c的纵向响应变量。
Although change-point analysis methods for longitudinal data have been developed, it is often of interest to detect multiple change-points in longitudinal data. In this paper, we propose a linear mixed effects modeling framework for identifying multiple change-points in longitudinal Gaussian data. Specifically, we develop a novel statistical and computational framework that integrates the Expectation-Maximization (E-M) and the Dynamic Programming (DP) algorithms. We conduct a comprehensive simulation study to demonstrate the performance of our method. Our method is illustrated with an analysis of data from a trial evaluating a behavioral intervention for the control of type I diabetes in adolescents with HbA1c as the longitudinal response variable.
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