Phase diagrams of lipid mixtures relevant to the study of membrane rafts.

Phase diagrams of lipid mixtures relevant to the study of membrane rafts.
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DOI:
10.1016/j.bbalip.2008.09.002
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发表时间:
2008-11
影响因子:
4.8
通讯作者:
Thewalt, Jenifer L.
Thewalt, Jenifer L.
中科院分区:
生物学2区
文献类型:
--
作者:
Goni, Felix M.;Alonso, Alicia;Bagatolli, Luis A.;Brown, Rhoderick E.;Marsh, Derek;Prieto, Manuel;Thewalt, Jenifer L.

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本文综述了磷脂酰胆碱-鞘磷脂-胆固醇混合物的相特性,该混合物通常用作膜“筏”微域的模型。基于 X 射线、显微镜和光谱观察、表面压力和量热测量以及洗涤剂溶解测定的可用数据,根据三角相图进行严格评估和合理化。其余的不确定性将与似乎存在共识的数据分开具体讨论。
The present paper reviews the phase properties of phosphatidylcholine-sphingomyelin-cholesterol mixtures, that are often used as models for membrane “raft” microdomains. The available data based on X-ray, microscopic and spectroscopic observations, surface pressure and calorimetric measurements, and detergent solubilization assays, are critically evaluated and rationalized in terms of triangular phase diagrams. The remaining uncertainties are discussed specifically and separately from the data on which a consensus appears to exist.
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