Heterogeneity in the responses of adjacent neurons to natural stimuli in cat striate cortex.
Heterogeneity in the responses of adjacent neurons to natural stimuli in cat striate cortex.
复制标题
猫纹状皮层相邻神经元对自然刺激反应的异质性。
DOI：
10.1152/jn.00747.2006
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发表时间：
2007
影响因子：
2.5
通讯作者：
C. Gray
中科院分区：
文献类型：
--
作者：
S. Yen;J. Baker;C. Gray
当呈现条形和格栅等简单刺激时，纹状皮质中的相邻神经元对多个刺激维度（例如方向、方向和空间频率）表现出共同的选择性。这导致了这样的想法，即神经元反应的局部平均提供了更可靠的刺激特性的表示。然而，当受到复杂的、时变的自然场景的刺激时（即，电影），纹状体神经元表现出高度稀疏的反应。这就提出了一个问题，即当受到电影刺激时，局部种群表现出多大的反应异质性，以及它如何随细胞之间的间隔距离而变化。我们研究了这个问题，同时记录的反应，在猫纹状皮层的神经元组的重复呈现的电影使用硅探针在多四极配置。我们发现，首先，纹状体神经元对电影的反应是短暂的（几十毫秒），去相关的，并表现出高度的群体稀疏性。第二，我们发现相邻的神经元即使对同一帧电影做出反应，它们的峰值放电率也有显著差异。第三，对相邻的神经元记录在同一个四极管表现出尽可能多的异质性，在他们的反应对记录不同的四极管。这些研究结果表明，复杂的自然场景引起高度异质性的反应，在当地人口，这表明在皮质柱的反应冗余大大低于以前认为的。
When presented with simple stimuli like bars and gratings, adjacent neurons in striate cortex exhibit shared selectivity for multiple stimulus dimensions, such as orientation, direction, and spatial frequency. This has led to the idea that local averaging of neuronal responses provides a more reliable representation of stimulus properties. However, when stimulated with complex, time-varying natural scenes (i.e., movies), striate neurons exhibit highly sparse responses. This raises the question of how much response heterogeneity the local population exhibits when stimulated with movies, and how it varies with separation distance between cells. We investigated this question by simultaneously recording the responses of groups of neurons in cat striate cortex to the repeated presentation of movies using silicon probes in a multi-tetrode configuration. We found, first, that the responses of striate neurons to movies are brief (tens of milliseconds), decorrelated, and exhibit high population sparseness. Second, we found that adjacent neurons differed significantly in their peak firing rates even when they responded to the same frames of a movie. Third, pairs of adjacent neurons recorded on the same tetrodes exhibited as much heterogeneity in their responses as pairs recorded by different tetrodes. These findings demonstrate that complex natural scenes evoke highly heterogeneous responses within local populations, suggesting that response redundancy in a cortical column is substantially lower than previously thought.
影响因子：
2.5
作者：
Blanche, TJ;Spacek, MA;Swindale, NV
通讯作者：
Swindale, NV
影响因子：
2.5
作者：
Harris, KD;Henze, DA;Buzsáki, G
通讯作者：
Buzsáki, G
DOI：
10.1364/josaa.4.002379
发表时间：
1987-12-01
影响因子：
1.9
作者：
FIELD, DJ
通讯作者：
FIELD, DJ