Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery.
Serum apolipoprotein B to apolipoprotein A-I ratio is an independent predictor of liver metastasis from locally advanced rectal cancer in patients receiving neoadjuvant chemoradiotherapy plus surgery.
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DOI：
10.1186/s12885-021-09101-y
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发表时间：
2022-01-03
期刊：
影响因子：
3.8
通讯作者：
Chang H
中科院分区：
文献类型：
--
作者：
Chen C;Yi W;Zeng ZF;Wang QX;Jiang W;Gao YH;Chang H
血清载脂蛋白B(ApoB)与载脂蛋白A-I(ApoAI)的比值是结直肠癌预后的重要指标。本研究旨在评价载脂蛋白B/载脂蛋白AI比值在预测直肠癌肝转移中的意义。本文回顾了599例局部晚期复发性复发性鼻咽癌患者的临床资料。分析血清载脂蛋白AI、载脂蛋白B及载脂蛋白B/载脂蛋白AI比值与患者无肝转移、无其他转移及总生存期的关系，以及患者手术前后的病理临床特征。单因素生存分析采用Kaplan-Meier方法，多因素生存分析采用Cox模型。计算独立预测因素的危险比(HR)和95%可信区间(CI)。糖类抗原19 − 9 ≥ 2 6.3U/ml、载脂蛋白B/载脂蛋白AI比值 ≥ 0.6 3、肿瘤消退5级 − 3、PT4和PN + 分期是无肝转移生存期较差的独立预测因素。危险比分别为1.656(95%CI，1.094~2.506)、1.919(95%CI，1.174~3.145)、1.686(95%CI，1.053~2.703)、1.890(95%CI，1.110~3.226)和2.012(95%CI，1.314~2.077)。除载脂蛋白B/载脂蛋白AI比值外，其他4个因素也是无其他转移和总生存期较差的独立预测因素。总体生存较差的独立预测因素还包括年龄 ≥ 67岁、距肛缘的距离 <； 5 cm。血清apoB/apoAI比值可作为预测局部晚期肝癌肝转移风险的生物标志物。网上版载有补充材料，可在10.1186/s12885-021-09101-y查阅。
The ratio of serum apolipoprotein B (apoB) to apolipoprotein A-I (apoAI) had been reported as a prognostic factor in colorectal cancer. This retrospective study aimed to assess the implication of apoB-to-apoAI ratio in predicting liver metastasis from rectal cancer (RC). The clinical data of 599 locally advanced RC patients treated with chemoradiotherapy followed by surgery were reviewed. Serum apoAI, apoB and apoB-to-apoAI ratio were analyzed for their correlation with the liver-metastasis-free, other-metastasis-free and overall survivals, together with the pretreatment and postsurgical pathoclinical features of the patients. Univariate and multivariate survival analyses were realized through the Kaplan-Meier approach and Cox model, respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for independent predictors. Carbohydrate antigen 19 − 9 ≥ 26.3 U/ml, apoB-to-apoAI ratio ≥ 0.63, tumor regression grade 5 − 3, pT4 and pN + stage emerged as independent predictors of poorer liver-metastasis-free survival. The hazard ratios were 1.656 (95% CI, 1.094–2.506), 1.919 (95% CI, 1.174–3.145), 1.686 (95% CI, 1.053–2.703), 1.890 (95% CI, 1.110–3.226) and 2.012 (95% CI, 1.314–2.077), respectively. Except apoB-to-apoAI ratio, the other 4 factors were also independent predictors of poorer other-metastasis-free and overall survivals. And the independent predictors of poorer overall survival also included age ≥ 67 years old, distance to anal verge < 5 cm. Serum apoB-to-apoAI ratio could be used as a biomarker for prediction of liver metastasis risk in locally advanced RC. The online version contains supplementary material available at 10.1186/s12885-021-09101-y.
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影响因子：
4.6
作者：
Sirniö P;Väyrynen JP;Klintrup K;Mäkelä J;Mäkinen MJ;Karttunen TJ;Tuomisto A
通讯作者：
Tuomisto A
影响因子：
1.6
作者：
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Han H
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影响因子：
2.9
作者：
Chen, Xiu-Qing;Wu, Pei-Wen;Yang, Li-Yong
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Yang, Li-Yong
影响因子：
3.9
作者：
Chang, Hui;Yu, Xin;Gao, Yuan-hong
通讯作者：
Gao, Yuan-hong
影响因子：
2.5
作者：
Ishimaru, Kazuhiro;Kawai, Kazushige;Ishihara, Soichiro
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