Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer.
Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer.
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DOI：
10.1038/s41598-017-05415-9
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发表时间：
2017-07-14
影响因子：
4.6
通讯作者：
Tuomisto A
中科院分区：
文献类型：
--
作者：
Sirniö P;Väyrynen JP;Klintrup K;Mäkelä J;Mäkinen MJ;Karttunen TJ;Tuomisto A
最近的研究报道，高血清载脂蛋白 A1 (APOA1) 水平与多种恶性肿瘤的良好预后之间存在关联，而载脂蛋白 B (APOB) 在癌症中的重要性则鲜为人知。在这项研究中，我们分析了 144 名结直肠癌 (CRC) 患者的血清 APOA1 和 APOB 水平以及 APOB/APOA1 比值之间的相关性，及其与临床病理参数、20 种全身炎症标志物水平和生存的关系。我们证明，低血清 APOA1 水平与晚期 T 级和 TNM 分期相关，但低血清 APOB 水平与肿瘤特征没有显着相关性。血清 APOA1 水平与血清 CRP 和白细胞介素 (IL)-8 水平以及血液中性粒细胞计数等全身炎症标志物呈强负相关，而高血清 APOB 水平与高血清 CCL2 水平相关。高 APOA1 和 APOB 水平以及低 APOB/APOA1 比率与改善癌症特异性和总体生存率相关。 APOA1在Cox回归分析中具有独立的预后价值。总之，低血清APOA1水平与晚期和全身炎症相关，而血清APOB与肿瘤分期没有显着相关性。血清 APOA1 代表了 CRC 中一个有前景的额外预后参数。
Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance of apolipoprotein B (APOB) in cancer is less well-known. In this study, we analyzed the correlation between serum APOA1 and APOB levels, and APOB/APOA1 ratio, and their associations with clinicopathologic parameters, the levels of twenty systemic inflammatory markers, and survival in 144 colorectal cancer (CRC) patients. We demonstrated that low serum APOA1 levels associated with advanced T-class and TNM-stage but low serum APOB levels did not significantly correlate with tumor characteristics. Serum APOA1 levels showed strong negative correlation with the markers of systemic inflammation including serum CRP and interleukin (IL)-8 levels and blood neutrophil count, whereas high serum APOB levels associated with high serum CCL2 levels. High APOA1 and APOB levels and low APOB/APOA1 ratio associated with improved cancer specific and overall survival. APOA1 had independent prognostic value in Cox regression analysis. In conclusion, low serum APOA1 levels are associated with advanced stage and systemic inflammation, while serum APOB does not significantly correlate with tumor stage. Serum APOA1 represents a promising additional prognostic parameter in CRC.
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影响因子：
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作者：
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通讯作者：
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通讯作者：
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