Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients.
Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients.
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DOI：
10.3390/ijms16023237
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发表时间：
2015-02-02
影响因子：
5.6
通讯作者：
Ranieri G
中科院分区：
文献类型：
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作者：
Ammendola M;Marech I;Sammarco G;Zuccalà V;Luposella M;Zizzo N;Patruno R;Crovace A;Ruggieri E;Zito AF;Gadaleta CD;Sacco R;Ranieri G
虽然胃癌是一种公认的血管生成驱动型肿瘤，但目前还没有关于胃癌骨转移患者中类胰蛋白酶阳性的肥大细胞(MCs)刺激血管生成的数据。巨噬细胞在免疫反应中的作用已经得到证实，最近又有研究表明，巨噬细胞参与了肿瘤血管生成。我们对组织学诊断为BMGCP的浸润性MC和新生血管进行了分析。从骨活检组织中筛选出15例T3-4N2-3M1(AJCC胃癌分期第7版)BMGCP。采用免疫组织化学和图像分析方法检测肿瘤组织中类胰蛋白酶阳性的巨噬细胞密度(MCDPT)、阳性面积(MCAPT)、微血管密度(MVD)和血管内皮细胞面积(EA)。经Pearson检验和t检验，MCDPT、MCAPT、MVD和EA四组间有显著相关性(r范围为0.68~0.82；p值为0.00~0.02)。我们的初步数据表明，类胰蛋白酶阳性的浸润性MC可能在BMGCP血管生成中发挥作用，并可进一步评估为抗血管生成治疗的新靶点。
While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by AJCC for Gastric Cancer Staging 7th Edition) BMGCP from bone biopsies were selected. Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of MCs density positive to tryptase (MCDPT), MCs area positive to tryptase (MCAPT), microvascular density (MVD) and endothelial area (EA). A significant correlation between MCDPT, MCAPT, MVD and EA groups to each other was found by Pearson and t-test analysis (r ranged from 0.68 to 0.82; p-value ranged from 0.00 to 0.02). Our very preliminary data suggest that infiltrating MCs positive for tryptase may play a role in BMGCP angiogenesis, and could be further evaluated as a novel target of anti-angiogenic therapy.
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影响因子：
--
作者：
Ammendola M;Leporini C;Marech I;Gadaleta CD;Scognamillo G;Sacco R;Sammarco G;De Sarro G;Russo E;Ranieri G
通讯作者：
Ranieri G
影响因子：
11.2
作者：
Morris, DR;Ding, Y;Trejo, J
通讯作者：
Trejo, J
影响因子：
3.2
作者：
Benítez-Bribiesca, L;Wong, A;Castellanos, E
通讯作者：
Castellanos, E
影响因子：
4.6
作者：
Kwon, Ji Yeon;Yun, Jina;Park, Hee Sook
通讯作者：
Park, Hee Sook
影响因子：
15.9
作者：
Blair, RJ;Meng, H;Gruber, BL
通讯作者：
Gruber, BL