Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene.
Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene.
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c-kis 作为甲基胆蒽诱导的纤维肉瘤中的转化基因的频繁激活。
DOI：
10.1126/science.6302839
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发表时间：
1983
期刊：
影响因子：
56.9
通讯作者：
S. Aaronson
中科院分区：
文献类型：
--
作者：
A. Eva;S. Aaronson
四种甲基胆蒽诱导的小鼠纤维肉瘤中的两种的 DNA 含有转化基因，这些基因在限制性内切核酸酶对生物活性失活的抵抗模式上是相同的。该转化基因被鉴定为 Kirsten 鼠肉瘤病毒 onc 基因 v-kis 的激活同源物。确定的致癌物可重复地导致 kis 作为转化基因被激活，这一发现对于阐明癌基因在肿瘤形成过程中的作用具有重要价值。
The DNA's from two of four methylcholanthrene-induced mouse fibrosarcomas contained transforming genes that were identical in their pattern of restriction endonuclease resistance to inactivation of biologic activity. This transforming gene was identified as the activated homolog of the Kirsten murine sarcoma virus onc gene, v-kis. The finding that a defined carcinogen reproducibly leads to activation of kis as a transforming gene should be of value in elucidating the role of oncogenes in the neoplastic process.
小鼠和人类乳腺癌中相关转化基因的激活。
DOI：
10.1073/pnas.78.8.5185
发表时间：
1981
影响因子：
11.1
作者：
Lane,MA;Sainten,A;Cooper,GM
通讯作者：
Cooper,GM