Zinc Finger Readers of Methylated DNA.
Zinc Finger Readers of Methylated DNA.
复制标题
甲基化DNA的锌指读取器。
DOI：
10.3390/molecules23102555
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发表时间：
2018-10-07
期刊：
影响因子：
--
通讯作者：
Buck-Koehntop BA
中科院分区：
文献类型：
--
作者：
Hudson NO;Buck-Koehntop BA
DNA甲基化是一种普遍存在的表观遗传修饰，参与调节许多重要的细胞过程，包括基因组可及性和转录结果。因此，全球DNA甲基化模式的异常改变与越来越多的疾病状况有关。然而，DNA甲基化信息被解释和翻译成基因组反应的完整机制尚未完全理解。甲基-CpG结合蛋白（MBP）通过选择性地阅读DNA甲基化信号并将该信息翻译成下游细胞结果而作为该基本过程的重要介质发挥作用。Cys 2 His 2锌指支架是在人类转录因子中发现的最丰富的DNA结合基序之一，然而只有少数含有锌指的蛋白质能够赋予mCpG相对于CpG位点的选择性。这篇综述总结了我们目前对锌指MBPs机制的结构理解，迄今为止，锌指MBPs评估了这一重要的表观遗传标记。此外，一些mCpG读出引起这个家庭的MBP的生物学意义进行了讨论。
DNA methylation is a prevalent epigenetic modification involved in regulating a number of essential cellular processes, including genomic accessibility and transcriptional outcomes. As such, aberrant alterations in global DNA methylation patterns have been associated with a growing number of disease conditions. Nevertheless, the full mechanisms by which DNA methylation information is interpreted and translated into genomic responses is not yet fully understood. Methyl-CpG binding proteins (MBPs) function as important mediators of this essential process by selectively reading DNA methylation signals and translating this information into down-stream cellular outcomes. The Cys2His2 zinc finger scaffold is one of the most abundant DNA binding motifs found within human transcription factors, yet only a few zinc finger containing proteins capable of conferring selectivity for mCpG over CpG sites have been characterized. This review summarizes our current structural understanding for the mechanisms by which the zinc finger MBPs evaluated to date read this essential epigenetic mark. Further, some of the biological implications for mCpG readout elicited by this family of MBPs are discussed.
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影响因子：
3.7
作者：
Buck-Koehntop BA;Defossez PA
通讯作者：
Defossez PA
影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
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Church, George M.
影响因子：
5.8
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通讯作者：
Abdelhay E
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6.2
作者：
Bassey-Archibong BI;Kwiecien JM;Milosavljevic SB;Hallett RM;Rayner LG;Erb MJ;Crawford-Brown CJ;Stephenson KB;Bédard PA;Hassell JA;Daniel JM
通讯作者：
Daniel JM
影响因子：
3.5
作者：
Buck-Koehntop BA;Martinez-Yamout MA;Dyson HJ;Wright PE
通讯作者：
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