Family history of hormonal cancers and colorectal cancer risk: a case-control study conducted in Ontario.
Family history of hormonal cancers and colorectal cancer risk: a case-control study conducted in Ontario.
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激素癌和大肠癌风险的家族史：在安大略省进行的一项病例对照研究。
DOI：
10.1002/ijc.24385
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发表时间：
2009-08-15
影响因子：
6.4
通讯作者：
Daftary D
中科院分区：
文献类型：
--
作者：
Jang JH;Cotterchio M;Gallinger S;Knight JA;Daftary D
具有高度渗透性基因突变（例如遗传性非息肉病性结直肠癌）的家族中癌症的聚集性已得到充分描述。然而，关于一般人群中激素癌症（乳腺癌、子宫内膜癌、卵巢癌和前列腺癌）和结直肠癌（CRC）的家族聚集性的数据很少。我们调查了乳腺癌、子宫内膜癌、卵巢癌或前列腺癌的一级家族史与结直肠癌风险之间的关系。安大略家族性结直肠癌登记处（OFCCR）招募了基于人群的CRC病例和对照。进行逻辑回归以获得比值比（OR）估计值和95%置信区间（95% CI）。乳腺癌一级家族史与中度、边缘性、统计学显著性CRC风险增加相关（年龄、性别校正OR = 1.2，95%CI = 1.0，1.5）。如果一个以上的一级亲属患有乳腺癌（年龄，性别调整的OR = 1.7，95%CI = 1.0，2.0），以及如果亲属在>50岁时被诊断出患有乳腺癌（年龄，性别调整的OR = 1.4，95%CI = 1.1，1.8），则CRC风险最大。卵巢癌家族史与CRC风险降低相关（多变量校正OR = 0.6，95%CI = 0.3，1.0）。虽然在子宫内膜癌和前列腺癌家族史的年龄、性别校正OR估计值中观察到CRC风险的统计学显著增加，但在多变量校正后，相关性不再显著。总之，有乳腺癌一级亲属的个体与没有乳腺癌的个体相比，患CRC的风险可能会适度增加。
Aggregation of cancers among families with highly penetrant genetic mutations such as hereditary nonpolyposis colorectal cancer is well-described. However, there is a paucity of data regarding familial aggregation of hormonal cancers (cancers of the breast, endometrial, ovarian, and prostate) and colorectal cancer (CRC) in the general population. We investigated the association between having a first-degree family history of breast, endometrial, ovarian, or prostate cancer and CRC risk. Population-based CRC cases and controls were recruited by the Ontario Familial Colorectal Cancer Registry (OFCCR). Logistic regression was conducted to obtain odds ratio (OR) estimates and 95% confidence intervals (95% CIs). First-degree family history of breast cancer was associated with a modest, borderline statistically significant increased CRC risk (age-, sex-adjusted OR = 1.2, 95% CI = 1.0, 1.5). The magnitude of CRC risk was greatest if more than one first-degree kin had breast cancer (age-, sex-adjusted OR = 1.7, 95% CI = 1.0, 2.0), as well as if the kin was diagnosed at >50 years of age (age-, sex-adjusted OR = 1.4, 95% CI = 1.1, 1.8). Family history of ovarian cancer was associated with reduced CRC risk (multivariate-adjusted OR = 0.6, 95% CI = 0.3, 1.0). While statistically significant increases in CRC risk were observed in the age-, sex-adjusted OR estimates for family history of endometrial and prostate cancers, the associations were no longer significant after multivariate-adjustment. In conclusion, individuals with a first-degree kin with breast cancer may have a modest increased risk for CRC compared to individuals without.
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