Effects of full-length kisspeptin administration on follicular development in Japanese Black beef cows.
Effects of full-length kisspeptin administration on follicular development in Japanese Black beef cows.
复制标题
DOI：
10.1262/jrd.2013-064
复制
发表时间：
2013-12-17
期刊：
影响因子：
--
通讯作者：
Ohkura S
中科院分区：
文献类型：
--
作者：
Naniwa Y;Nakatsukasa K;Setsuda S;Oishi S;Fujii N;Matsuda F;Uenoyama Y;Tsukamura H;Maeda K;Ohkura S
Kisspeptin是通过释放促性腺激素释放激素（GnRH）刺激促性腺激素分泌的关键分子。在本研究中，我们的目的是调查是否kisspeptin通过促性腺激素释放激素（GnRH）/促性腺激素分泌对奶牛卵泡发育有刺激作用。在日本黑肉牛显示站立发情后5天（第0天），静脉注射全长牛kisspeptin [Kp-53（0.2或2 nmol/kg）]或溶剂。在注射2 nmol/kg Kp-53的奶牛中，第6天及之后第一个优势卵泡的卵泡大小增加。在以2 nmol/kg的Kp-53处理的4头奶牛中，有1头发生第一优势卵泡排卵。注射Kp-53在2 nmol/kg增加血浆促黄体生成素（LH）的浓度，但不是卵泡刺激素，在4小时内注射后，在所有的奶牛。目前的研究表明，全长kisspeptin的管理导致LH分泌，这是持续几个小时，它是能够刺激卵泡发育和/或排卵。
Kisspeptin is a key molecule that stimulates gonadotropin secretion via release of gonadotropin-releasing hormone (GnRH). In the present study, our aim was to investigate whether kisspeptin has stimulatory effects on follicular development via GnRH/gonadotropin secretion in cows. Japanese Black beef cows were intravenously injected with full-length bovine kisspeptin [Kp-53 (0.2 or 2 nmol/kg)] or vehicle 5 days after they exhibited standing estrus (Day 0). In cows injected with Kp-53 at 2 nmol/kg, the follicular sizes of the first dominant follicles increased on Day 6 and thereafter. Ovulation of the first dominant follicle occurred in 1 out of 4 cows treated with Kp-53 at 2 nmol/kg. Injection of Kp-53 at 2 nmol/kg increased the concentration of plasma luteinizing hormone (LH) but not follicle-stimulating hormone, over a 4-h period following injection in all cows. The present study suggests that administration of full-length kisspeptin causes LH secretion, which is sustained for a few hours, and it is capable of stimulating follicular development and/or ovulation.
登录
查看更多内容
影响因子：
3.3
作者：
Busch, D. C.;Atkins, J. A.;Smith, M. F.
通讯作者：
Smith, M. F.
DOI：
10.1073/pnas.1834399100
发表时间：
2003-09-16
影响因子：
11.1
作者：
de Roux, N;Genin, E;Milgrom, E
通讯作者：
Milgrom, E
影响因子：
4.8
作者：
de Tassigny, Xavier d'Anglemont;Fagg, Lisa A.;Colledge, William H.
通讯作者：
Colledge, William H.
影响因子：
4.8
作者：
JOHNSON, AK;GROSS, PM
通讯作者：
GROSS, PM
影响因子：
1.8
作者：
Adachi, Sachika;Yamada, Shunji;Maeda, Kei-Ichiro
通讯作者：
Maeda, Kei-Ichiro