Polymorphism of the insulin gene is associated with increased prostate cancer risk.
Polymorphism of the insulin gene is associated with increased prostate cancer risk.
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DOI：
10.1038/sj.bjc.6600747
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发表时间：
2003-01-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
高胰岛素水平与癌症风险增加有关，包括前列腺癌。我们研究了前列腺癌与胰岛素基因（INS）及其邻近基因酪氨酸羟化酶和IGF-II（TH和IGF 2）多态性之间的关系。在这项研究中，对126例年龄、种族和原籍国匹配的病例对照对进行基因分型，INS为+1127 INS-PstI，TH为-4217 TH-PstI，IGF 2为+3580 IGF 2-MspI。在60%以上的人群中出现了+1127 INS-Pst Ⅰ纯合子CC基因型。在非糖尿病黑人和白人中，它与前列腺癌风险增加相关（OR=3.14，P=0.008）。CC基因型还与低Gleason评分<7（OR=2.60，P=0.022）和诊断年龄晚（OR=2.10，P=0.046）相关。INS邻近基因中的标记物仅显示与前列腺癌无至中度相关。INS基因多态性可能在前列腺癌的发病机制中起一定作用。鉴于CC基因型的高患病率及其与低级别肿瘤发病年龄晚的相关性，这种多态性可能有助于前列腺癌的独特特征，即惰性癌症的高患病率和发病率随年龄的急剧增加。
High insulin levels are linked with increased cancer risk, including prostate cancer. We examined the associations between prostate cancer with polymorphisms of the insulin gene (INS) and its neighbouring genes, tyrosine-hydroxylase and IGF-II (TH and IGF2). In this study, 126 case–control pairs matched on age, race, and countries of origin were genotyped for +1127 INS-PstI in INS, –4217 TH-PstI in TH, and +3580 IGF2-MspI in IGF2. The homozygous CC genotype of +1127 INS-PstI occurred in over 60% of the population. It was associated with an increased risk of prostate cancer in nondiabetic Blacks and Caucasians (OR=3.14, P=0.008). The CC genotype was also associated with a low Gleason score <7 (OR=2.60, P=0.022) and a late age of diagnosis (OR=2.10, P=0.046). Markers in the neighbouring genes of INS showed only null to modest associations with prostate cancer. The polymorphism of INS may play a role in the aetiology of prostate cancer. Given the high prevalence of the CC genotype and its association with late age of onset of low-grade tumours, this polymorphism may contribute to the unique characteristics of prostate cancer, namely a high prevalence of indolent cancers and the dramatic increase in incidence with age.
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