Maternal depression and prenatal exposure to methamphetamine: neurodevelopmental findings from the infant development, environment, and lifestyle (ideal) study.
Maternal depression and prenatal exposure to methamphetamine: neurodevelopmental findings from the infant development, environment, and lifestyle (ideal) study.
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DOI：
10.1002/da.21956
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发表时间：
2012-06
影响因子：
7.4
通讯作者：
Lester, Barry M.
中科院分区：
文献类型：
--
作者：
Smith, Lynne M.;Paz, Monica S.;LaGasse, Linda L.;Derauf, Chris;Newman, Elana;Shah, Rizwan;Arria, Amelia;Huestis, Marilyn A.;Haning, William;Strauss, Arthur;Della Grotta, Sheri;Dansereau, Lynne M.;Neal, Charles;Lester, Barry M.
母亲抑郁症与婴儿行为问题的发生率较高，但早在1个月的母亲抑郁症的影响还没有得到很好的表征。本研究的目的是使用NICU网络神经行为量表（NNNS）确定母亲抑郁对接触和未接触甲基苯丙胺（MA）的婴儿的神经行为影响。入组了412对母婴（MA = 204），目前的分析仅包括监护孩子的亲生母亲。在1个月访视时（n = 126例MA暴露; n = 193例MA未暴露），进行贝克抑郁量表-II（BDI-II），并对婴儿进行NNNS给药。通过自我报告和/或气相色谱/质谱确认新生儿胎粪中的苯丙胺和代谢物来确定暴露。未暴露的受试者是匹配的，否认使用安非他明，胎粪筛查阴性。一般线性模型测试了母亲抑郁和产前MA暴露对NNNS的影响，P <0.05时具有显著性。MA组抑郁症阳性诊断的发生率增加，BDI-II抑郁评分增加。在调整协变量后，MA暴露与唤醒和处理分数增加以及自我调节能力下降相关。母亲抑郁症与较高的自主神经应激和较差的运动质量有关。在母亲抑郁并在怀孕期间使用MA的婴儿中没有观察到额外的差异。母亲抑郁症与压力增加和运动质量下降的神经发育模式有关，这表明母亲抑郁症会影响1个月大的婴儿的神经发育。
Maternal depression is associated with a higher incidence of behavioral problems in infants, but the effects of maternal depression as early as 1 month are not well characterized. The objective of this study is to determine the neurobehavioral effects of maternal depression on infants exposed and not exposed to methamphetamine (MA) using the NICU Network Neurobehavioral Scale (NNNS). Four hundred twelve mother–infant pairs were enrolled (MA = 204) and only biological mothers with custody of their child were included in the current analysis. At the 1-month visit (n = 126 MA-exposed; n = 193 MA-unexposed), the Beck Depression Inventory-II (BDI-II) was administered, and the NNNS was administered to the infant. Exposure was identified by self-report and/or gas chromatography/mass spectroscopy confirmation of amphetamine and metabolites in newborn meconium. Unexposed subjects were matched, denied amphetamine use, and had negative meconium screens. General Linear Models tested the effects of maternal depression and prenatal MA exposure on NNNS, with significance accepted at P < .05. The MA group had an increased incidence of depression-positive diagnosis and increased depression scores on the BDI-II. After adjusting for covariates, MA exposure was associated with increased arousal and handling scores, and a decreased ability to self-regulate. Maternal depression was associated with higher autonomic stress and poorer quality of movement. No additional differences were observed in infants whose mothers were both depressed and used MA during pregnancy. Maternal depression is associated with neurodevelopmental patterns of increased stress and decreased quality of movement, suggesting maternal depression influences neurodevelopment in infants as young as 1 month.
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影响因子：
2.3
作者：
GATEWOODCOLWELL, G;KACZMAREK, M;AMES, MH
通讯作者：
AMES, MH
影响因子：
9.8
作者：
Bauer, CR;Shankaran, S;Verter, J
通讯作者：
Verter, J
影响因子：
5.3
作者：
Chang, Trina;Fava, Maurizio
通讯作者：
Fava, Maurizio
DOI：
10.1367/a04-207r.1
发表时间：
2005-11-01
期刊：
AMBULATORY PEDIATRICS
影响因子：
--
作者：
Kavanaugh, M;McMillen, RC;Weitzman, M
通讯作者：
Weitzman, M
DOI：
10.1007/s00737-003-0024-6
发表时间：
2003-11-01
期刊：
Archives of women's mental health
影响因子：
--
作者：
Grace, S L;Evindar, A;Stewart, D E
通讯作者：
Stewart, D E