Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry
Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry
复制标题
皮层可塑性中配对联想刺激的功效和时间过程：对神经精神病学的影响
DOI：
10.1016/j.clinph.2015.04.072
复制
发表时间：
2016
影响因子：
4.7
通讯作者：
D. Schutter
中科院分区：
文献类型：
--
作者：
M. Wischnewski;D. Schutter
配对联想刺激（PAS）已被用于研究正常和异常的皮层可塑性。然而，迄今尚未提供考绩制度影响的规范性审查。为此，PAS协议的幅度和时间过程中进行了系统的evaluationhere.MethodsA文献检索PubMed使用的搜索术语配对联想刺激进行。主要纳入标准是在健康志愿者的初级运动皮层进行实验，干预前未进行运动训练，运动诱发电位作为主要结局指标。结果PAS LTP对健康志愿者皮层兴奋性水平的增强作用（PASLTP）和抑制作用（PASLTD）在90 min内对皮层兴奋性水平的增强作用（最大±标准误差38.5 ± 3.3%）可靠而稳定。PASLTP在0.05和0.2Hz频率下应用时最有效。PASLTD研究的分析表明，皮质兴奋性水平的可靠和稳定的抑制长达120分钟（最大±标准误差-23.0 ± 1.9%）结论PAS显著调节皮质兴奋性。PASLTP的增强作用强于PASLTD.SignificancePresent研究结果的抑制作用提供了规范的PASLTP和PASLTD诱导的皮质兴奋性水平的变化的幅度和时间过程的见解。
ObjectivePaired associative stimulation (PAS) has been used to study normal and abnormal cortical plasticity. However, a normative review of PAS effects has not been provided so far. To this end, the magnitude and time course of PAS protocols was systematically evaluated here.MethodsA literature search in PubMed using the search termpaired associative stimulationwas conducted. Main inclusion criteria were that experiments were conducted in primary motor cortex of healthy volunteers without motor training before intervention and motor evoked potentials as primary outcome measure. This search yielded in total 104 experiments, which were analyzed to examine the potentiating (PASLTP) and depressing effects of PAS (PASLTD) on cortical excitability levels in healthy volunteers.ResultsPASLTPinduces reliable and stable potentiating effects (maximum ± standard error 38.5 ± 3.3%) on cortical excitability levels up to 90 min. PASLTPwas most effective when applied at frequencies of 0.05 and 0.2 Hz. Analyses of the PASLTDstudies demonstrated reliable and stable depression of cortical excitability levels up to 120 min (maximum ± standard error −23.0 ± 1.9%)ConclusionsPAS significantly modulates cortical excitability. The potentiating effects of PASLTPare stronger than the depressing effects for PASLTD.SignificancePresent findings offer normative insights into the magnitude and time course of PASLTPand PASLTD-induced changes in cortical excitability levels.
登录
查看更多内容
PAS 后脊髓兴奋性的变化。
影响因子：
2.5
作者：
Meunier,Sabine;Russmann,Heike;Simonetta-Moreau,Marion;Hallett,Mark
通讯作者：
Hallett,Mark
配对联想刺激引起的皮质脊髓兴奋性抑制的微电路机制
DOI：
10.1113/jphysiol.2013.253989
发表时间：
2013
期刊：
The Journal of Physiology
影响因子：
--
作者：
Ridding;Michael;Eskandar;Martin;Jost-Julian
通讯作者：
Jost-Julian
影响因子：
2.5
作者：
Yang, SN;Tang, YG;Zucker, RS
通讯作者：
Zucker, RS
诱导人类初级运动皮层抑制联想可塑性的新时间窗口
影响因子：
4.7
作者：
Schabrun;Ridding;Classen
通讯作者：
Classen