The role of Neuregulin-1beta/ErbB signaling in the heart.
The role of Neuregulin-1beta/ErbB signaling in the heart.
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DOI：
10.1016/j.yexcr.2008.08.015
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发表时间：
2009-02-15
影响因子：
3.7
通讯作者：
Sawyer DB
中科院分区：
文献类型：
--
作者：
Pentassuglia L;Sawyer DB
Neuregulin-1（Nrg-1）基因的产物，沿着Nrg-1配体信号传导所通过的受体酪氨酸激酶的ErbB家族，在心血管发育过程中起关键作用。通过对基因操纵小鼠的研究，以及对成年心脏分离细胞的研究，似乎Nrg-1/ErbB信号传导是细胞-细胞相互作用的重要旁分泌介质，不仅在发育过程中调节组织，而且有助于维持整个生物体的心脏功能。从心脏分离的细胞中的研究表明，Nrg-1可以激活许多信号通路，这些信号通路介导心肌细胞对应激的适应。这些观察结果提供了关于为什么ErbB 2靶向癌症治疗对一些癌症患者的心脏功能有有害影响的见解。此外，新出现的数据表明，Nrg-1配体可能是有用的临床恢复心脏损伤后的心脏功能。在这篇综述中，我们将试图综合这一快速增长和令人兴奋的研究领域背后的文献。
Products of the Neuregulin-1 (Nrg-1) gene, along with the ErbB family of receptor tyrosine kinases through which Nrg-1 ligands signal, play a critical role during cardiovascular development. Through studies of genetically manipulated mice, as well as studies in cells isolated from adult hearts, it appears that Nrg-1/ErbB signaling is an essential paracrine mediator of cell–cell interactions that not only regulates tissue organization during development, but also helps to maintain cardiac function throughout an organism's life. Studies in cells isolated from the heart demonstrate that Nrg-1 can activate a number of signaling pathways, which mediate cellular adaptations to stress in the myocardium. These observations provide insight as to why ErbB2-targeted cancer treatments have deleterious effects on cardiac function in some cancer patients. Moreover emerging data suggest that Nrg-1 ligands might be useful clinically to restore cardiac function after cardiac injury. In this review we will attempt to synthesize the literature behind this rapidly growing and exciting area of research.
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DOI：
10.1152/ajpheart.00453.2004
发表时间：
2005-01-01
影响因子：
4.8
作者：
Das, S;Cordis, GA;Das, DK
通讯作者：
Das, DK
影响因子：
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影响因子：
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DOI：
10.1152/ajpheart.1994.267.6.h2138
发表时间：
1994-12-01
影响因子：
4.8
作者：
GRAFE, M;AUCHSCHWELK, W;FLECK, E
通讯作者：
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影响因子：
5
作者：
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通讯作者：
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