The role of prolactin in autoimmune demyelination: Suppression of experimental allergic encephalomyelitis by bromocriptine
The role of prolactin in autoimmune demyelination: Suppression of experimental allergic encephalomyelitis by bromocriptine
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催乳素在自身免疫性脱髓鞘中的作用：溴隐亭抑制实验性过敏性脑脊髓炎
作者：
P. Riskind;L. Massacesi;T. Doolittle;S. Hauser
多项证据表明，垂体前叶激素催乳素对免疫功能具有刺激作用，多巴胺激动剂溴隐亭对催乳素分泌的药理学抑制可抑制体液和细胞免疫。在这里，我们描述了催乳素抑制对雌性刘易斯大鼠实验性过敏性脑脊髓炎病程的影响。免疫前开始连续溴隐亭治疗可降低急性实验性过敏性脑脊髓炎临床体征的严重程度和发生率。实验性过敏性脑脊髓炎免疫大鼠经历了三倍的基础催乳素水平的上升，免疫后第4天，并保持在第10天，神经症状的实验性过敏性脑脊髓炎的发病前升高的催乳素水平。溴隐亭治疗降低催乳素水平的shamimmunized大鼠。体内溴隐亭预处理抑制体外脾淋巴细胞对免疫抗原和伴刀豆球蛋白A的增殖反应。此外，溴隐亭治疗是保护性的，当开始1周后，首次免疫接种，也是有效的抑制晚期疾病。这些结果表明（1）在免疫后和实验性变态反应性脑脊髓炎发作前催乳素水平升高，（2）溴隐亭抑制催乳素分泌和急性实验性变态反应性脑脊髓炎的严重程度，和（3）在致敏后开始治疗时也存在抑制，提示在实验性变态反应性脑脊髓炎期间，prolaction对免疫应答的效应肢的影响。
Several lines of evidence suggest that the anterior pituitary hormone prolactin has a stimulatory role on immune function and that pharmacological suppression of prolactin secretion with the dopamine‐agonist bromocriptine suppresses both humoral and cellular immunity. Here, we describe the effects of prolactin‐suppression on the course of experimental allergic encephalomyelitis in female Lewis rats. Initiation of continuous bromocriptine treatment before immunization reduced both the severity and incidence of clinical signs of acute experimental allergic encephalomyelitis. Experimental allergic encephalomyelitis–immunized rats experienced a threefold rise in basal prolactin levels on day 4 after immunization and maintained elevated prolactin levels on day 10, before the onset of neurological signs of experimental allergic encephalomyelitis. Bromocriptine treatment reduced prolactin levels to those of shamimmunized rats. In vivo bromocriptine pretreatment inhibited splenic lymphocyte proliferative responses in vitro to the immunizing antigen and to concanavalin A. Moreover, bromocriptine therapy was protective when initiated 1 week after the initial immunization and was also effective in suppression of late disease. These results indicate that (1) prolactin levels are elevated after immunization and before the onset of experimental allergic encephalomyelitis, (2) bromocriptine inhibits both prolactin secretion and the severity of acute experimental allergic encephalomyelitis, and (3) inhibition is also present when treatment is begun after sensitization, suggesting an effect of prolaction on the effector limb of the immune response during experimental allergic encephalomyelitis.
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有证据表明促甲状腺素释放激素不是大鼠哺乳期间主要的催乳素释放因子。
影响因子：
4.8
作者：
Riskind,PN;Millard,WJ;Martin,JB
通讯作者：
Martin,JB
影响因子：
4.8
作者：
MUKHERJEE, P;MASTRO, AM;HYMER, WC
通讯作者：
HYMER, WC
Interleukin-6 在体外刺激垂体前叶激素释放。
影响因子：
4.8
作者：
Spangelo,BL;Judd,AM;Isakson,PC;MacLeod,RM
通讯作者：
MacLeod,RM
催乳素刺激体内抗体产生和刀豆球蛋白 A 诱导的小鼠脾细胞有丝分裂。
DOI：
10.1016/0162-3109(87)90004-x
发表时间：
1987
期刊：
Immunopharmacology
影响因子：
--
作者：
Spangelo,BL;Hall,NR;Ross,PC;Goldstein,AL
通讯作者：
Goldstein,AL