Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice.
Perinatal Combinational Exposure to Bisphenol A and a High-Fat Diet Contributes to Transgenerational Dysregulation of Cardiovascular and Metabolic Systems in Mice.
复制标题
围产期同时接触双酚 A 和高脂肪饮食会导致小鼠心血管和代谢系统的跨代失调
DOI：
10.3389/fcell.2022.834346
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发表时间：
2022
影响因子：
5.5
通讯作者：
Xiao X
中科院分区：
文献类型：
--
作者：
Liu J;Liao M;Huang R;You Y;Lin X;Yang H;Fan L;Zhong Y;Li X;Li J;Xiao X
双酚A（BPA）和高脂饮食（HFD）对动物和人类都有不利影响，而且会影响后代的健康。BPA和HFD通常在现代生活方式中共存;然而，母亲在围产期同时暴露于BPA和HFD对后代心血管和代谢系统的长期影响尚不清楚。本研究旨在研究母亲同时暴露于BPA和HFD对后代代谢和心血管异常风险的影响。癌症研究所雌性小鼠（F0）在妊娠前和妊娠期间暴露于BPA并喂食HFD，直至哺乳期结束。将F0小鼠与未给药雄性小鼠交配以产生第一代（F1）;随后，将成年F1雄性/雌性小鼠与正常雌性/雄性小鼠交配以产生第二代（F2）。母体暴露于BPA和HFD可导致心肌肥大和主动脉图尼卡中膜增厚，并增加母系F2代心肌细胞的横截面积和血压。这些心血管变化可能与内皮型一氧化氮合酶（eNOS）水平降低有关。父系女性F2比父系男性F2更容易肥胖。用HFD重新喂养显示出更显著的体重增加和能量消耗减少。然而，在围产期单独暴露于HFD或BPA时未观察到上述影响。我们的研究结果表明，围产期联合暴露于BPA和HFD可能会导致代谢和心血管疾病的后代，此外，我们的研究结果表明，HFD和BPA的协同效应可以传递给后代的性别依赖的方式。
Both bisphenol A (BPA) and high-fat diet (HFD) exert unfavorable effects on animals and humans; moreover, they could affect the health of their offspring. BPA and HFD often coexist in modern lifestyles; however, the long-term effects of simultaneous exposure of mothers to BPA and HFD during the perinatal period on the cardiovascular and metabolic systems of the offspring remain unclear. This study aimed to examine the effect of simultaneous exposure of mothers to BPA and HFD on the risk of metabolic and cardiovascular abnormalities in offspring. Institute of Cancer Research female mice (F0) were exposed to BPA and fed with HFD before and during gestation until the end of lactation. F0 mice were mated with untreated males to produce the first generation (F1); subsequently, adult F1 males/females were mated with normal females/males to produce the second generation (F2). Combined maternal exposure to BPA and HFD caused myocardial hypertrophy and aortic tunica media thickening as well as increased the cross-sectional area of cardiomyocytes and blood pressure in the matrilineal F2 generation. These cardiovascular changes might be associated with reduced endothelial nitric oxide synthase (eNOS) levels. The patrilineal female F2 was more likely to be obese than the patrilineal male F2. Re-feeding with a HFD showed a more significant weight gain and reduced energy expenditure. However, the aforementioned effects were not observed with exposure to HFD or BPA alone during the perinatal period. Our findings suggest that perinatal combinational exposure to BPA and HFD could cause metabolic and cardiovascular disorders in the offspring, Further, our findings demonstrate that the synergistic effects of HFD and BPA could be transmitted to future generations in a sex-dependent manner.
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影响因子：
20.3
作者：
Kautzky-Willer A;Harreiter J;Pacini G
通讯作者：
Pacini G
影响因子：
37.8
作者：
Höchsmann C;Dorling JL;Martin CK;Newton RL Jr;Apolzan JW;Myers CA;Denstel KD;Mire EF;Johnson WD;Zhang D;Arnold CL;Davis TC;Fonseca V;Lavie CJ;Price-Haywood EG;Katzmarzyk PT;PROPEL Research Group
通讯作者：
PROPEL Research Group
影响因子：
4
作者：
Lecoutre, Simon;Deracinois, Barbara;Breton, Christophe
通讯作者：
Breton, Christophe
影响因子：
3.2
作者：
Jeon JY;Ha KH;Kim DJ
通讯作者：
Kim DJ
影响因子：
8.9
作者：
Gao, Xiaona;Liu, Shuhui;Song, Suquan
通讯作者：
Song, Suquan