Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.
Robot-Applied Resistance Augments the Effects of Body Weight-Supported Treadmill Training on Stepping and Synaptic Plasticity in a Rodent Model of Spinal Cord Injury.
复制标题
机器人应用的电阻增强了体重支持的跑步机训练对啮齿动物脊髓损伤模型中的踩踏和突触可塑性的影响。
DOI：
10.1177/1545968317721016
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发表时间：
2017-08
影响因子：
4.2
通讯作者：
de Leon RD
中科院分区：
文献类型：
--
作者：
Hinahon E;Estrada C;Tong L;Won DS;de Leon RD
为了改善脊髓损伤(SCI)后的步行功能，在体重支持的跑步机训练(BWSTT)中使用了阻力的应用。这种形式的训练是否真的增强了BWSTT的效果尚不清楚。在脊髓损伤的啮齿动物模型中，采用对照实验设计，确定机器人施加的阻力是否增加了BWSTT的效果。脊髓挫伤大鼠在跑步机上进行训练，用机器人抵抗水平运动(n=9)或垂直运动(n=8)后肢运动。在训练前和训练6周后进行后肢踏步测试。两个对照组，一个接受标准训练(即没有抵抗；n=9)和一个没有训练(n=8)，也被测试。在终末实验中，制备脊髓，进行突触素免疫组织化学分析。6周的水平阻力训练增加了步长，而垂直阻力训练提高了台阶高度和运动速度。这些变化都没有发生在接受标准(即没有抵抗)训练的组或未训练的组中。只有标准训练增加了台阶周期的数量，缩短了周期周期，使其接近正常值。水平阻力训练组和未训练组大鼠腹角突触素表达最高，且与步长呈正相关。在BWSTT中加入机器人应用的阻力，比单独使用BWSTT在运动功能上有所改善。阻力对脊髓连接的影响可能取决于脊髓损伤后阻力的性质和突触环境。
The application of resistive forces has been used during body weight supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is not yet known. To determine if robotic-applied resistance augments the effects of BWSTT using a controlled experimental design in a rodent model of SCI. Spinally contused rats were treadmill trained using robotic resistance against horizontal (n=9) or vertical movements (n=8) hindlimb movements. Hindlimb stepping was tested before and after 6 weeks of training. Two control groups, one receiving standard training (i.e. without resistance; n=9) and one untrained (n=8), were also tested. At the terminal experiment, the spinal cords were prepared for immunohistochemical analysis of synaptophysin. Six weeks of training with horizontal resistance increased step length while training with vertical resistance enhanced step height and movement velocity. None of these changes occurred in the group that received standard (i.e. no resistance) training or in the untrained group. Only standard training increased the number of step cycles and shortened cycle period toward normal values. Synaptophysin expression in the ventral horn was highest in rats trained with horizontal resistance and in untrained rats and was positively correlated with step length. Adding robotic-applied resistance to BWSTT produced gains in locomotor function over BWSTT alone. The impact of resistive forces on spinal connections may depend on the nature of the resistive forces and the synaptic milieu that is present after SCI.
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影响因子：
2.4
作者：
Macias M;Nowicka D;Czupryn A;Sulejczak D;Skup M;Skangiel-Kramska J;Czarkowska-Bauch J
通讯作者：
Czarkowska-Bauch J
影响因子：
4.2
作者：
de Leon, Ray D.;Acosta, Cynthia N.
通讯作者：
Acosta, Cynthia N.
影响因子：
5.3
作者：
Kuerzi, J.;Brown, E. H.;Magnuson, D. S. K.
通讯作者：
Magnuson, D. S. K.
DOI：
10.1523/jneurosci.3499-11.2011
发表时间：
2011-12-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cantoria MJ;See PA;Singh H;de Leon RD
通讯作者：
de Leon RD
影响因子：
3.7
作者：
Krishnan C;Ranganathan R;Dhaher YY;Rymer WZ
通讯作者：
Rymer WZ