Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, pistafolia A.
Scavenging of reactive oxygen species and prevention of oxidative neuronal cell damage by a novel gallotannin, pistafolia A.
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一种新型棓单宁 Pistafolia A 清除活性氧并预防氧化神经元细胞损伤。
DOI：
10.1016/s0024-3205(02)01494-7
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发表时间：
2002-03
期刊：
影响因子：
6.1
通讯作者：
侯京武等
中科院分区：
文献类型：
--
作者：
卫涛涛;赵兴宇;侯京武等
阿月浑子A是从阿月浑子叶提取物中分离得到的一种新的没食子单宁。本文采用ESR自旋捕集技术研究了黄连木甲对活性氧自由基的清除能力。研究了脂质体对铁诱导的脂质过氧化反应的抑制作用。还评估了Pistafolia A对过氧亚硝基阴离子诱导的氧化性神经细胞损伤和凋亡的保护作用。结果表明，黄连木甲对羟自由基和超氧阴离子有剂量依赖性的清除作用，并能有效地抑制脂质过氧化反应。在小脑颗粒细胞预处理Pistafolia A，过氧亚硝基诱导的氧化神经元损伤和凋亡的预防显着。Pistafolia A的抗氧化能力比维生素E的水溶性类似物Trolox强得多。结果提示，黄连木甲可作为一种有效的天然抗氧化剂，用于预防和治疗与过氧亚硝基阴离子及相关活性氧产生有关的神经元疾病。
Pistafolia A is a novel gallotannin isolated from the leaf extract of Pistacia weinmannifolia. In the present investigation, the ability of Pistafolia A to scavenge reactive oxygen species including hydroxyl radicals and superoxide anion was measured by ESR spin trapping technique. The inhibition effect on iron-induced lipid peroxidaiton in liposomes was studied. The protective effects of Pistafolia A against oxidative neuronal cell damage and apoptosis induced by peroxynitrite were also assessed. The results showed that Pistafolia A could scavenge both hydroxyl radicals and superoxide anion dose-dependently and inhibit lipid peroxidation effectively. In cerebellar granule cells pretreated with Pistafolia A, peroxynitrite-induced oxidative neuronal damage and apoptosis were prevented markedly. The antioxidant capacity of Pistafolia A was much more potent then that of the water-soluble analog of vitamin E, Trolox. The results suggested that Pistafolia A might be used as an effective natural antioxidant for the prevention and cure of neuronal diseases associated with the production of peroxynitrite and related reactive oxygen species.
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影响因子：
3.3
作者：
Michael Aviram
通讯作者：
Michael Aviram
影响因子：
2.7
作者：
A. Hou;Li-Yan Peng;Yan-ze Liu;Zhongwen Lin;Han-Dong Sun
通讯作者：
A. Hou;Li-Yan Peng;Yan-ze Liu;Zhongwen Lin;Han-Dong Sun
影响因子：
3.9
作者：
A. Diplock
通讯作者：
A. Diplock
DOI：
10.1016/s0005-2760(96)00122-1
发表时间：
1996-12-13
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM
影响因子：
--
作者：
Guo, QN;Zhao, BL;Xin, WJ
通讯作者：
Xin, WJ
影响因子：
2.5
作者：
Ni, YC;Zhao, BL;Xin, WJ
通讯作者：
Xin, WJ