Lifetime physical activity and the incidence of proliferative benign breast disease.
Lifetime physical activity and the incidence of proliferative benign breast disease.
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DOI：
10.1007/s10552-011-9803-y
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发表时间：
2011-09
影响因子：
2.3
通讯作者：
Tamimi, Rulla M.
中科院分区：
文献类型：
--
作者：
Jung, Michelle M.;Colditz, Graham A.;Collins, Laura C.;Schnitt, Stuart J.;Connolly, James L.;Tamimi, Rulla M.
锻炼是一种可改变的因素，与患乳腺癌的风险成反比。为了确定体育锻炼是否对乳腺癌前病变的发生具有预防作用，我们研究了锻炼与增生性良性乳腺疾病发病率之间的关系。1997年，护士健康研究II队列使用一种经过验证的回忆工具报告了青春期和成年期的体力活动水平。我们前瞻性地跟踪了40,318名没有患BBD或癌症的参与者四年，并通过集中病理回顾确认了232个增生性良性乳腺病变。Cox比例风险模型估计了年龄调整和多变量调整的体力活动和增生性良性乳腺疾病(BBD)的相对风险。我们观察到步行与BBD发病率呈显著负相关，每小时步行的风险降低9%(95%可信区间0%至17%)，(p趋势=0.05)。尽管有少数病例，但柱状细胞损害的风险也与剧烈活动呈负相关(每周剧烈活动4小时或更长时间的RR=0.62；与每周1小时的RR=0.31-1.22)。这项研究表明，锻炼可能与患增生性良性乳房疾病的风险成反比，增生性良性乳房疾病是乳腺癌发生的最早步骤之一。
Exercise is a modifiable factor that is inversely related to risk for breast cancer. To determine if physical activity has a preventative effect on development of premalignant breast lesions, we examined the association between exercise and the incidence of proliferative benign breast disease. In 1997, the Nurses’ Health Study II cohort reported levels of physical activity during adolescence and adulthood using a validated recall instrument. We followed 40,318 participants free from BBD or cancer prospectively for four years and confirmed 232 proliferative benign breast lesions by centralized pathology review. Cox proportional hazards models estimated the age-adjusted and multivariable-adjusted relative risks for physical activity and proliferative benign breast disease (BBD). We observed a significant inverse association for walking and incidence of BBD, risk was reduced by 9% per hour of walking (95% CI 0% to 17%), (p trend=0.05). Despite a small number of cases, risk of columnar cell lesions also suggested an inverse association with strenuous activity (RR for 4 or more hours of strenuous activity per week = 0.62; 0.31–1.22 compared to <1 hour per week). This study suggests that exercise may be inversely associated with the risk of developing proliferative benign breast disease, one of the earliest steps in the development of breast cancer.
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影响因子：
4.2
作者：
Friedenreich, CM;Orenstein, MR
通讯作者：
Orenstein, MR
影响因子：
7.2
作者：
Thorpe, Kevin E.;Zwarenstein, Merrick;Chalkidou, Kalipso
通讯作者：
Chalkidou, Kalipso
影响因子：
3.8
作者：
Baer, HJ;Schnitt, SJ;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
5
作者：
HISLOP, TG;BAND, PR;LABO, T
通讯作者：
LABO, T
影响因子：
5.4
作者：
ChasanTaber, S;Rimm, EB;Willett, WC
通讯作者：
Willett, WC