Most cases of Thrombosis and Thrombocytopenia Syndrome (TTS) post ChAdOx-1 nCov-19 are Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT).
Most cases of Thrombosis and Thrombocytopenia Syndrome (TTS) post ChAdOx-1 nCov-19 are Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT).
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DOI：
10.1016/j.lanepe.2021.100274
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Pavord S
中科院分区：
文献类型：
--
作者：
Makris M;Pavord S
疫苗诱导的免疫性血栓性血小板减少症（VITT）是最近在接受ChAdOx1冠状病毒-19疫苗的少数个体中观察到的一种综合征，于2021年3月首次发现。主要特征是在腺病毒SARS-CoV-2疫苗接种5À30天内血小板减少和血栓形成，d -二聚体水平显著升高，抗pf4抗体存在。在本期杂志上发表的一篇论文中，来自最初描述该综合征的一个小组的2位作者报告了德国国家VITT患者队列的最新临床和实验室数据。该报告将来自两个来源的数据联系起来，提供了一个亚组患者的全面概述。临床细节来自德国保罗-埃利希研究所（PEI）报告的106例血栓和血小板减少综合征（TTS）病例，该研究所报告了接种ChAdOx-1 nCoV-19疫苗后的不良事件。106例TTS患者中有52例（49%）在Greifswald实验室进行了抗pf4检测，该实验室是抗pf4研究和检测的国际卓越中心。52例TTS患者抗pf4 IgG ELISA检测均为阳性，确认诊断为VITT。德国TTS和VITT队列的特征与英国报道的VITT相似1（表1）。与英国相比，德国女性患者的比例相对较高，这反映了德国更多的女性接种了ChAdOx-1 nCoV-19疫苗
Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT) is a recently recognised syndrome observed in a small number of individuals who received the ChAdOx1 CoV-19 vaccine and was first identified in March 2021. The main features are thrombocytopenia and thrombosis within 5À30 days of adenoviral SARS-CoV-2 vaccination, with markedly elevated levels of D-dimer and presence of anti-PF4 antibodies. 1 In a paper published in the current issue of the journal, 2 authors from one of the groups that initially described the syndrome 3 report updated clinical and laboratory data on the German national cohort of VITT patients. 2The report links data from two sources to provide a comprehensive overview of a subgroup of the patients. The clinical details were obtained from the 106 cases of thrombosis and thrombocytopenia syndrome (TTS) reported to the Paul-Ehrlich-Institute (PEI), the German Agency where adverse events are reported, following vaccination with the ChAdOx-1 nCoV-19 vaccine. 52 (49%) of the 106 TTS patients had their anti-PF4 testing at the Greifswald laboratory, an internationally centre of excellence for anti-PF4 research and testing. All 52 TTS patients tested for anti-PF4 using an IgG ELISA were positive, considered as confirmation of the diagnosis as VITT. The characteristics of the German TTS and VITT cohorts are similar to those reported with VITT from the UK 1 (Table 1). The relative higher proportion of female patients in Germany compared to the UK, reflects the fact that more females received the ChAdOx-1 nCoV-19 vaccine in Germany. 2
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DOI：
10.1056/nejmoa2104840
发表时间：
2021-06-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Greinacher A;Thiele T;Warkentin TE;Weisser K;Kyrle PA;Eichinger S
通讯作者：
Eichinger S
影响因子：
10.4
作者：
Platton, Sean;Bartlett, Andrew;Pavord, Sue
通讯作者：
Pavord, Sue
影响因子：
158.5
作者：
Greinacher, Andreas
通讯作者：
Greinacher, Andreas
影响因子：
158.5
作者：
Pavord, Sue;Scully, Marie;Makris, Mike
通讯作者：
Makris, Mike