Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes
Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes
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受到有害皮肤刺激后，猫背角中免疫反应性神经激肽 A 的释放、扩散和持续存在。
DOI：
10.1016/0306-4522(90)90134-p
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发表时间：
1990
期刊：
影响因子：
3.3
通讯作者：
S. Fleetwood
中科院分区：
文献类型：
--
作者：
A. Duggan;P. J. Hope;Bevyn Jarrott;H. Schaible;S. Fleetwood
在巴比妥麻醉脊髓猫抗体微探针被用来检查释放免疫反应神经激肽A皮肤热和机械刺激。在没有外周刺激的情况下，微探针检测到免疫反应性神经激肽A的弥漫性基底存在。有害的机械刺激和较小程度的有害热刺激会弥漫性增加整个背角的免疫反应性神经激肽A的水平，在许多情况下，这些神经激肽A会扩散到邻近的白色物质中。这些弥散性刺激诱发的增加与以前的实验相反，在以前的实验中，相同的刺激产生免疫反应物质P水平的离散局灶性增加。获得的证据表明，释放的免疫反应神经激肽A在脊髓中持续至少30分钟，超过刺激时间。几个实验室发现，一些脊髓神经元的兴奋性持续增加，跟随来自无髓鞘初级传入神经的短暂输入。
In barbiturate anaesthetized spinal cats antibody microprobes were used to examine release of immunoreactive neurokinin A following cutaneous thermal and mechanical stimulation. In the absence of peripheral stimuli, microprobes detected a diffuse basal presence of immunoreactive neurokinin A. Noxious mechanical and to a lesser extent noxious thermal stimuli increased the levels of immunoreactive neurokinin A diffusely throughout the dorsal horn which, in many cases, spread into the adjacent white matter. These diffuse stimulus-evoked increases contrast with previous experiments where the same stimuli produced discrete focal increases in levels of immunoreactive substance P. Evidence was obtained that released immunoreactive neurokinin A persisted in the spinal cord for at least 30 min beyond the period of stimulation.Neurokinin A needs consideration as the agent responsible for the long-lasting increases in excitability of some spinal neurons found by several laboratories to follow a brief input from unmyelinated primary afferents.
DOI：
10.1073/pnas.84.3.881
发表时间：
1987-02-01
影响因子：
11.1
作者：
KRAUSE, JE;CHIRGWIN, JM;HERSHEY, AD
通讯作者：
HERSHEY, AD