Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study.
Grandmaternal smoking, asthma and lung function in the offspring: the Lifelines cohort study.
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DOI：
10.1136/thoraxjnl-2020-215232
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发表时间：
2021-05
期刊：
影响因子：
10
通讯作者：
Vonk JM
中科院分区：
文献类型：
--
作者：
Mahon GM;Koppelman GH;Vonk JM
关于祖母在怀孕期间吸烟与孙辈患哮喘和肺功能改变的风险之间的关系，研究有限。本研究的目的是在三代设计中研究这种关联。37291名参与者（25747名成人和11544名儿童）来自生命线研究，这是一项在荷兰进行的前瞻性纵向三代队列研究。69.5%和61.1%的纳入成人和儿童可进行肺功能测定。采用Logistic回归和线性回归分析祖母吸烟与（1）哮喘、（2）儿童早期哮喘（6岁以前发病）和（3）肺功能水平的关系。母亲和父亲的祖父母吸烟分别进行了研究，并按成人/儿童和性别进行分层分析。分析调整了性别，目前吸烟，出生变量和社会经济地位。在成年人群中，男性中，母亲祖母在怀孕期间吸烟与哮喘（OR（95% CI）：1.38（1.06 - 1.79））、儿童早期哮喘（1.49（95% CI 1.06 - 2.11））和FEV 1/FVC%预测值较低（B（95% CI）：−1.04（−1.91-−0.16））的风险较高相关。在对参与这项研究的儿童进行的单独分析中没有观察到这些发现。父亲祖母吸烟与哮喘/肺功能之间也没有显着关联。母亲在怀孕期间吸烟与男性孙子的哮喘风险较高和肺功能较低有关，并对后代的男性孙子产生相反的影响。我们的研究强调了吸烟对几代人的根深蒂固的影响。
Limited research exists regarding the association between grandmaternal smoking during pregnancy and the risk for asthma and altered lung function in grandchildren. This study aimed to investigate this association in a three-generation design. 37 291 participants (25 747 adults and 11 544 children) were included from the Lifelines study, a prospective longitudinal three generation cohort study in The Netherlands. Spirometry was available in 69.5% and 61.1% of the included adults and children. Logistic and linear regression were used to analyse the association between grandmaternal smoking during pregnancy and (1) asthma, (2) early childhood asthma (ie, onset before 6 years) and (3) lung function level. Maternal and paternal grandmaternal smoking were studied separately and the analyses were stratified by adult/child and by gender. The analyses were adjusted for gender, current smoking, birth variables and socioeconomic status. In the adult population, maternal grandmaternal smoking during pregnancy was associated with a higher risk for asthma (OR (95% CI): 1.38 (1.06 to 1.79)), early childhood asthma (1.49 (95% CI 1.06 to 2.11)) and a lower FEV1/FVC% predicted (B (95% CI): −1.04 (−1.91 to −0.16) in men. These findings were not observed in a separate analysis of children that participated in this study. There was also no significant association between paternal grandmaternal smoking and asthma/lung function. Maternal grandmaternal smoking during pregnancy is associated with higher asthma risk and lower lung function in male grandchildren and a reverse effect in male grandchildren of subsequent generations. Our study highlights the deep-rooted effects of tobacco smoking across generations.
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发表时间：
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期刊：
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影响因子：
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