Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations.
Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations.
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3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
ERS Global Lung Function Initiative
中科院分区：
文献类型：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
推导出适用于全球的肺功能指数的连续预测方程及其正常下限。来自33个国家72个中心的16万多个数据点与欧洲呼吸学会全球肺功能倡议共享。排除无法使用的数据（大部分缺失的种族群体，一些离群值），留下97，759条2.5-95岁的健康非吸烟者（55.3%女性）记录。整理肺功能数据，并使用LMS（λ，µ，σ）方法推导预测方程，该方法允许同时对分布族的平均值（mu）、变异系数（sigma）和偏度（lambda）进行建模。在丢弃23，572条记录后，主要是因为它们无法与其他种族或地理群体相结合，推导出3-95岁健康个体的参考方程，包括高加索人（N= 57，3 - 95），非洲裔美国人（N= 3，545），北方人（N= 4，992）和东南亚人（N= 8，255）。不同种族组间FEV 1和FVC的比例与白人不同，因此FEV 1/FVC几乎与种族组无关。对于不属于这四个群体的个人或混合族裔的个人，提供了一个综合方程，作为上述方程的平均值，以便于解释，直到找到更合适的解决办法。现在可获得3-95岁年龄范围的肺活量预测方程，其中包括适当的年龄依赖性正常下限。它们可以在全球适用于不同的族裔群体。来自印度次大陆、阿拉伯、波利尼西亚、拉丁美洲国家和非洲的其他数据将在未来进一步完善这些方程。
Derive continuous prediction equations and their lower limits of normal for spirometric indices, which are applicable globally. Over 160,000 data points from 72 centres in 33 countries were shared with the European Respiratory Society Global Lung Function Initiative. Eliminating data that could not be used (mostly missing ethnic group, some outliers) left 97,759 records of healthy nonsmokers (55.3% females) aged 2.5–95 years. Lung function data were collated, and prediction equations derived using the LMS (λ, µ, σ) method, which allows simultaneous modelling of the mean (mu), the coefficient of variation (sigma) and skewness (lambda) of a distribution family. After discarding 23,572 records, mostly because they could not be combined with other ethnic or geographic groups, reference equations were derived for healthy individuals from 3–95 years for Caucasians (N=57,395), African Americans (N=3,545), and North (N=4,992) and South East Asians (N=8,255). FEV1 and FVC between ethnic groups differed proportionally from that in Caucasians, such that FEV1/FVC remained virtually independent of ethnic group. For individuals not represented by these four groups, or of mixed ethnic origins, a composite equation taken as the average of the above equations is provided to facilitate interpretation until a more appropriate solution is developed. Spirometric prediction equations for the 3–95 age range are now available that include appropriate age-dependent lower limits of normal. They can be applied globally to different ethnic groups. Additional data from the Indian subcontinent, Arab, Polynesian, Latin American countries, and Africa will further improve these equations in the future.
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通讯作者：
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作者：
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通讯作者：
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