Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors.
Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors.
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DOI：
10.3390/pharmaceutics12111007
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发表时间：
2020-10-22
期刊：
影响因子：
5.4
通讯作者：
Ten Hagen TLM
中科院分区：
文献类型：
--
作者：
Amin M;Huang W;Seynhaeve ALB;Ten Hagen TLM
纳米技术通过设计稳定或长循环的纳米载体，在化疗药物的制剂、减少副作用和增强药代动力学方面具有强大的能力。然而，通过此类载体在细胞水平上的有效药物递送仍然不能令人满意。一种有前途的方法是通过纳米颗粒进行时空药物释放，纳米颗粒具有由内部或外部刺激触发内容物释放的能力。在不同的刺激中，人们对应用外部热量、热疗的兴趣正在增长。先进的技术、易于使用以及最重要的是对所施加的热量的高水平控制，从而触发释放，以及高热在增强化疗药物（即热化疗）的治疗反应中的辅助作用，使得高热成为触发药物释放的巨大刺激。因此，已经制造和研究了多种基于脂质或/和聚合物的温度敏感纳米载体。重要的是，为了实现有效的治疗结果，并考虑到热化疗的优点，纳米载体的释放特性应适合适用的临床热设置。在这里，我们介绍和讨论三种研究最多的温度敏感纳米颗粒的应用，重点是释放行为及其在适用性和治疗潜力方面的重要性。
Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.
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影响因子：
4.4
作者：
Anyarambhatla, GR;Needham, D
通讯作者：
Needham, D
影响因子：
8
作者：
Amin, Mohamadreza;Bagheri, Mahsa;ten Hagen, Timo L. M.
通讯作者：
ten Hagen, Timo L. M.
影响因子：
10.8
作者：
Chung, JE;Yokoyama, M;Okano, T
通讯作者：
Okano, T
影响因子：
10.8
作者：
Eggen, Siv;Fagerland, Stein-Martin;Davies, Catharina de lange
通讯作者：
Davies, Catharina de lange
DOI：
10.1016/s0360-3016(96)00389-6
发表时间：
1996-12-01
影响因子：
7
作者：
Gaber, MH;Wu, NZ;Papahadjopoulos, D
通讯作者：
Papahadjopoulos, D