Modelling neural entrainment and its persistence: influence of frequency of stimulation and phase at the stimulus offset
Modelling neural entrainment and its persistence: influence of frequency of stimulation and phase at the stimulus offset
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模拟神经夹带及其持续性：刺激频率和刺激偏移处相位的影响
DOI：
10.1101/2021.09.10.459802
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Otero M
中科院分区：
文献类型：
--
作者：
Otero M
神经夹带，大脑振荡与外部刺激频率的同步，是塑造感知和认知过程的关键机制。使用模拟，我们研究了神经夹带的动力学，特别是刺激结束后的一段时间，因为（混响）神经夹带可能条件未来的感觉表征的基础上预测刺激的节奏。改进的Jansen-Rit神经质量模型（NMM）的耦合皮质柱，其中的输出的频谱特征类似于脑电图（EEG）。我们评估了作为刺激频率、包括NMM的神经群体的共振频率和皮质柱之间的耦合强度的函数的夹带的频谱-时间特征。此外，我们测试，如果夹带的持久性取决于在刺激endows.Main ResultsThe夹带收到的刺激的列的EEG样振荡的相位时，是最大的频率时，该柱的共振频率在一个狭窄的范围内。当这种情况发生时，夹带持续几个周期后，刺激终止，和夹带的传播到其他列的促进。传播还取决于第二柱的谐振频率，以及柱之间的耦合强度。持续时间的夹带依赖于神经振荡的阶段时，终止，这样下降阶段（从π/2到3π/2的正弦函数）导致比上升相更长的持续时间（从0到π/2和3π/2到2π）。意义该研究在神经振荡模型和经验电生理学之间架起了桥梁，为神经夹带和使用节律性感觉刺激增强神经功能的机制提供了见解。
Neural entrainment, the synchronization of brain oscillations to the frequency of an external stimuli, is a key mechanism that shapes perceptual and cognitive processes.ObjectiveUsing simulations, we investigated the dynamics of neural entrainment, particularly the period following the end of the stimulation, since the persistence (reverberation) of neural entrainment may condition future sensory representations based on predictions about stimulus rhythmicity.MethodsNeural entrainment was assessed using a modified Jansen-Rit neural mass model (NMM) of coupled cortical columns, in which the spectral features of the output resembled that of the electroencephalogram (EEG). We evaluated spectro-temporal features of entrainment as a function of the stimulation frequency, the resonant frequency of the neural populations comprising the NMM, and the coupling strength between cortical columns. Furthermore, we tested if the entrainment persistence depended on the phase of the EEG-like oscillation at the time the stimulus ended.Main ResultsThe entrainment of the column that received the stimulation was maximum when the frequency of the entrainer was within a narrow range around the resonant frequency of the column. When this occurred, entrainment persisted for several cycles after the stimulus terminated, and the propagation of the entrainment to other columns was facilitated. Propagation also depended on the resonant frequency of the second column, and the coupling strength between columns. The duration of the persistence of the entrainment depended on the phase of the neural oscillation at the time the entrainer terminated, such that falling phases (from π/2 to 3π/2 in a sine function) led to longer persistence than rising phases (from 0 to π/2 and 3π/2 to 2π).SignificanceThe study bridges between models of neural oscillations and empirical electrophysiology, providing insights to the mechanisms underlying neural entrainment and the use of rhythmic sensory stimulation for neuroenhancement.
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