Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA).
Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA).
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DOI：
10.1016/j.jacc.2017.10.044
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发表时间：
2017-12-26
影响因子：
24
通讯作者：
Bluemke DA
中科院分区：
文献类型：
--
作者：
Liu CY;Heckbert SR;Lai S;Ambale-Venkatesh B;Ostovaneh MR;McClelland RL;Lima JAC;Bluemke DA
血清N-末端B型利钠肽原（NT-proBNP）被认为是一种标记物，在心肌应变和可能的纤维化反应中表达。然而，在社区人群中与心肌纤维化的关系尚不清楚。作者在梅萨（多种族动脉粥样硬化研究）研究中评价了心脏磁共振（CMR）纤维化指标与NT-proBNP水平之间的关系。在6个研究中心，共有1，334名受试者（52%白色、23%黑人、11%中国人、14%西班牙裔和52%男性，平均年龄67.6岁）在1.5 T下进行了血清NT-proBNP测量和CMR以及纤维化指数的T1标测。进行单变量和多变量回归分析，调整人口统计学、心血管风险因素和左心室（LV）质量，以检查log NT-proBNP与CMR T1标测指数的相关性。在完全校正的模型中，NT-proBNP每增加1个标准差（0.44 pg/ml），细胞外容积分数增加0.62%（p < 0.001），分配系数增加0.011（p < 0.001），天然T1增加4.7 ms（p = 0.001）。排除临床心血管疾病或晚期钆增强个体（n = 167）后，以及在回归模型中用LV舒张末期容积替代LV质量后，结果保持不变。NT-proBNP升高与基于社区的亚临床纤维化相关（动脉粥样硬化的多种族研究[梅萨];）（J Am科尔Cardiol 2017;70：3102-9）由Elsevier代表美国心脏病学会基金会发表。
Serum N-terminal pro–B-type natriuretic peptide (NT-proBNP) is considered a marker that is expressed in response to myocardial strain and possibly fibrosis. However, the relationship to myocardial fibrosis in a community-based population is unknown. The authors evaluated the relationship between cardiac magnetic resonance (CMR) measures of fibrosis and NT-proBNP levels in the MESA (Multi-Ethnic Study of Atherosclerosis) study. A total of 1,334 participants (52% white, 23% black, 11% Chinese, 14% Hispanic, and 52% men with a mean age of 67.6 years) at 6 sites had both serum NT-proBNP measurements and CMR with T1 mapping of indices of fibrosis at 1.5 T. Univariate and multivariable regression analyses adjusting for demographics, cardiovascular risk factors, and left ventricular (LV) mass were performed to examine the association of log NT-proBNP with CMR T1 mapping indices. In the fully adjusted model, each 1-SD increment (0.44 pg/ml) of log NT-proBNP was associated with a0.62% increment in extracellular volume fraction (p < 0.001), 0.011 increment in partition coefficient (p < 0.001), and 4.7-ms increment in native T1 (p = 0.001). Results remained unchanged after excluding individuals with clinical cardiovascular disease or late gadolinium enhancement (n = 167), and after replacing LV mass by LV end-diastolic volume in the regression models. Elevated NT-proBNP is related to subclinical fibrosis in a community-based setting. (Multi-Ethnic Study of Atherosclerosis [MESA]; ) (J Am Coll Cardiol 2017;70:3102–9) Published by Elsevier on behalf of the American College of Cardiology Foundation.
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DOI：
10.1161/circheartfailure.116.003553
发表时间：
2017-03
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Akwo EA;Kabagambe EK;Wang TJ;Harrell FE Jr;Blot WJ;Mumma M;Gupta DK;Lipworth L
通讯作者：
Lipworth L
细胞外体积定量在孤立的高血压 - 可检测到的限制下变化？
DOI：
10.1186/s12968-015-0176-3
发表时间：
2015-08-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Treibel TA;Zemrak F;Sado DM;Banypersad SM;White SK;Maestrini V;Barison A;Patel V;Herrey AS;Davies C;Caulfield MJ;Petersen SE;Moon JC
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Moon JC
影响因子：
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作者：
Savarese, Gianluigi;Hage, Camilla;Lund, Lars H.
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影响因子：
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作者：
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3
作者：
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