Revisiting Species Distribution and Antifungal Susceptibility of Candida Bloodstream Isolates from Latin American Medical Centers.
Revisiting Species Distribution and Antifungal Susceptibility of Candida Bloodstream Isolates from Latin American Medical Centers.
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DOI：
10.3390/jof3020024
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发表时间：
2017-05-17
期刊：
影响因子：
--
通讯作者：
Colombo AL
中科院分区：
文献类型：
--
作者：
da Matta DA;Souza ACR;Colombo AL
念珠菌症的流行病学因地域而异，关于拉丁美洲(LA)的念珠菌症流行病学的数据仍然很少。经过对医学文献的广泛修改，我们发现了来自洛杉矶国家21个医疗中心中的11个和来自加勒比国家/地区的20个医疗中心中的1个的患者关于念珠菌血症的微生物方面的可靠和可靠的信息。根据参加我们的搜索策略的40篇论文，我们注意到白色念珠菌仍然是导致本地区白念珠菌感染的最常见物种，其次是近平假丝酵母菌和热带假丝酵母菌。在阿根廷、巴西和哥伦比亚，观察到光滑念珠菌感染频率增加的趋势。虽然对氟康唑的耐药率在3%以下，但对白色念珠菌、近缘念珠菌和热带念珠菌的耐药率略有上升。棘球绦虫耐药性在一些调查中已有报道，但还没有一项研究用分子方法证实所报道的耐药表型。我们强调进行持续监测研究的重要性，以确定与洛杉矶念珠菌病发作相关的念珠菌种类分布和抗真菌耐药性的新趋势。这些信息对于帮助临床医生预防和控制医疗中心的念珠菌血流感染至关重要。
The epidemiology of candidemia varies geographically, and there is still scarce data on the epidemiology of candidemia in Latin America (LA). After extensive revision of medical literature, we found reliable and robust information on the microbiological aspects of candidemia in patients from 11 out of 21 medical centers from LA countries and 1 out of 20 from Caribbean countries/territories. Based on 40 papers attending our search strategy, we noted that C. albicans remains the most common species causing candidemia in our region, followed by C. parapsilosis and C. tropicalis. In Argentina, Brazil, and Colombia, a trend towards an increase in frequency of C. glabrata candidemia was observed. Although resistance rates to fluconazole is under 3%, there was a slight increase in the resistance rates to C. albicans, C. parapsilosis and C. tropicalis isolates. Echinocandin resistance has been reported in a few surveys, but no single study confirmed the resistant phenotype reported by using molecular methods. We highlight the importance of conducting continuous surveillance studies to identify new trends in terms of species distribution of Candida and antifungal resistance related to episodes of candidemia in LA. This information is critical for helping clinicians to prevent and control Candida bloodstream infections in their medical centers.
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影响因子：
38.9
作者：
Colombo, Arnaldo L.;Guimares, Thais;Sukienik, Teresa;Pasqualotto, Alessandro C.;Andreotti, Ricardo;Queiroz-Telles, Flavio;Nouer, Simone A.;Nucci, Marcio
通讯作者：
Nucci, Marcio
影响因子：
4.9
作者：
Ben-Ami, Ronen;Olshtain-Pops, Keren;Giladi, Michael
通讯作者：
Giladi, Michael
影响因子：
3.4
作者：
Aquino, Valério Rodrigues;Lunardi, Luciano W.;Barth, Afonso Luis
通讯作者：
Barth, Afonso Luis
影响因子：
38.9
作者：
Bassetti, Matteo;Righi, Elda;Tumbarello, Mario
通讯作者：
Tumbarello, Mario
影响因子：
4.9
作者：
Bizerra, Fernando Cesar;Jimenez-Ortigosa, Cristina;Colombo, Arnaldo L.
通讯作者：
Colombo, Arnaldo L.