Association between different combination of measures for obesity and new-onset gallstone disease.
Association between different combination of measures for obesity and new-onset gallstone disease.
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DOI：
10.1371/journal.pone.0196457
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Liu T;Wang W;Ji Y;Wang Y;Liu X;Cao L;Liu S
身体质量指数(BMI)是衡量一般肥胖的一个计算指标。腰围(WC)是衡量身体脂肪分布的指标，通常被用来评估腹部肥胖。一般肥胖症和腹型肥胖症的一个重要特征是它们共存的倾向。使用单一的肥胖测量方法不能准确地估计GSD的风险人群。本研究旨在比较不同肥胖指标组合(BMI、WC、腰臀比)对新发GSD的预测价值。我们前瞻性地研究了各种肥胖指标组合对新发GSD的预测价值，队列中有88,947名参与者，他们没有既往的胆结石疾病，记录了人口学特征和生化参数。在713 345人年的随访中，88,947名参与者中有4,329名参与者被确认患有GSD。较高的BMI、腰围和腰臀比(WHtR)在两性中都与GSD的风险显著相关，即使在调整了潜在的混杂因素后也是如此。男性BMI、WC、WHtR最高与最低的危险比分别为1.63(1.47~1.79)、1.53(1.40~1.68)、1.44(1.31~1.58)。女性BMI、WC、WHtR最高与最低的危险比分别为2.11(1.79~2.49)、1.85(1.55~2.22)、1.84(1.55~2.19)。在男性组，依次将BMI+WC组合加入多变量模型后，BMI+WC组合对模型预测能力的改善更为明显，而对女性来说，最好的预测组合是BMI+WHtR。在对潜在混杂因素进行额外调整后，BMI、WC和WHtR升高是新发GSD的独立危险因素。在男性中，BMI+WC的组合似乎是评估肥胖对新发GSD影响的最可预测的模型，而在女性中，最佳组合是BMI+WHtR。
Body mass index(BMI) is a calculation index of general obesity. Waist circumference(WC) is a measure of body-fat distribution and always used to estimate abdominal obesity. An important trait of general obesity and abdominal obesity is their propensity to coexist. Using one single measure of obesity could not estimate persons at risk for GSD precisely. This study aimed to compare the predictive values of various combination of measures for obesity(BMI, WC, waist to hip ratio) for new-onset GSD. We prospectively studied the predictive values of various combination of measures for obesity for new-onset GSD in a cohort of 88,947 participants who were free of prior gallstone disease, demographic characteristics and biochemical parameters were recorded. 4,329 participants were identified to have GSD among 88,947 participants during 713 345 person-years of follow-up. Higher BMI, WC and waist to hip ratio (WHtR) were significantly associated with higher risks of GSD in both genders even after adjustment for potential confounders. In males, the hazard ratio for the highest versus lowest BMI, WC, WHtR were 1.63(1.47~1.79), 1.53(1.40~1.68), 1.44(1.31~1.58), respectively. In females, the hazard ratio for the highest versus lowest BMI, WC, WHtR were 2.11(1.79~2.49), 1.85(1.55~2.22), 1.84(1.55~2.19), respectively. In male group, the combination of BMI+WC improved the predictive ability of the model more clearly than other combinations after adding them to the multivariate model in turn, while for females the best predictive combination was BMI+WHtR. Elevated BMI, WC and WHtR were independent risk factors for new-onset GSD in both sex groups after additional adjustment was made for potential confounders. In males, the combination of BMI+WC seemed to be the most predictable model to evaluate the effect of obesity on new-onset GSD, while the best combination in females was BMI+WHtR.
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DOI：
10.15585/mmwr.mm6717a2
发表时间：
2018-05-04
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Guglielmo D;Hootman JM;Murphy LB;Boring MA;Theis KA;Belay B;Barbour KE;Cisternas MG;Helmick CG
通讯作者：
Helmick CG
影响因子：
5
作者：
HAFFNER, SM;DIEHL, AK;HAZUDA, HP
通讯作者：
HAZUDA, HP
影响因子：
2.7
作者：
Matta, Joane;Carette, Claire;Czernichow, Sebastien
通讯作者：
Czernichow, Sebastien
影响因子：
5.1
作者：
Sebo, Paul;Beer-Borst, Sigrid;Bovier, Patrick A.
通讯作者：
Bovier, Patrick A.
影响因子：
29.4
作者：
Ruhl CE;Everhart JE
通讯作者：
Everhart JE