Polyethylene glycol as a promising synthetic material for repair of spinal cord injury.
Polyethylene glycol as a promising synthetic material for repair of spinal cord injury.
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聚乙二醇作为一种有前景的脊髓损伤修复合成材料
DOI：
10.4103/1673-5374.208597
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发表时间：
2017-06
影响因子：
6.1
通讯作者：
Sun ZL
中科院分区：
文献类型：
--
作者：
Kong XB;Tang QY;Chen XY;Tu Y;Sun SZ;Sun ZL
聚乙二醇是一种合成的、可生物降解的、水溶性聚醚。聚乙二醇具有良好的生物学和材料学特性，在脊髓组织工程中具有广阔的应用前景。虽然研究已经检查了用聚乙二醇修复脊髓损伤，但这些令人信服的发现最近尚未作为一个整体进行审查或评估。因此，我们在此回顾和总结了国内外研究聚乙二醇修复脊髓损伤的结果。以下总结了单独使用聚乙二醇以及与聚合物或水凝胶偶联的研究结果：（1）聚乙二醇作为可调节的生物分子载体，在脊髓损伤急性期抵抗神经纤维变性，减少炎症反应，抑制空泡和瘢痕形成，保护神经膜。(2)聚乙二醇偶联聚合物不仅促进血管生成，而且还将药物或生物活性分子携带到损伤部位。由于这类聚合物可以穿过血-脊髓和血-脑屏障，因此被广泛用作药物载体。(3)聚乙二醇水凝胶已被用作损伤后干细胞生长的支持基质，诱导细胞迁移、增殖和分化。同时，聚乙二醇水凝胶隔离或减少局部胶质瘢痕侵袭，促进和引导轴突再生，穿过移植区域，并重新建立与靶组织的突触连接，从而促进脊髓修复。在回顾研究的基础上，我们得出结论，聚乙二醇是一种很有前途的用于脊髓损伤修复的合成材料
Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineering applications. Although studies have examined repairing spinal cord injury with polyethylene glycol, these compelling findings have not been recently reviewed or evaluated as a whole. Thus, we herein review and summarize the findings of studies conducted both within and beyond China that have examined the repair of spinal cord injury using polyethylene glycol. The following summarizes the results of studies using polyethylene glycol alone as well as coupled with polymers or hydrogels: (1) polyethylene glycol as an adjustable biomolecule carrier resists nerve fiber degeneration, reduces the inflammatory response, inhibits vacuole and scar formation, and protects nerve membranes in the acute stage of spinal cord injury. (2) Polyethylene glycol-coupled polymers not only promote angiogenesis but also carry drugs or bioactive molecules to the injury site. Because such polymers cross both the blood-spinal cord and blood-brain barriers, they have been widely used as drug carriers. (3) Polyethylene glycol hydrogels have been used as supporting substrates for the growth of stem cells after injury, inducing cell migration, proliferation, and differentiation. Simultaneously, polyethylene glycol hydrogels isolate or reduce local glial scar invasion, promote and guide axonal regeneration, cross the transplanted area, and re-establish synaptic connections with target tissue, thereby promoting spinal cord repair. On the basis of the reviewed studies, we conclude that polyethylene glycol is a promising synthetic material for use in the repair of spinal cord injury
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影响因子：
14
作者：
Burdick, JA;Ward, M;Langer, R
通讯作者：
Langer, R
影响因子：
4.2
作者：
Laverty, PH;Leskovar, A;Borgens, RB
通讯作者：
Borgens, RB
影响因子：
4.7
作者：
Huo, Shuaidong;Chen, Shizhu;Liang, Xing-Jie
通讯作者：
Liang, Xing-Jie
影响因子：
17.1
作者：
Cui, Jiwei;De Rose, Robert;Caruso, Frank
通讯作者：
Caruso, Frank
影响因子：
10.8
作者：
Kang, Catherine E.;Tator, Charles H.;Shoichet, Molly S.
通讯作者：
Shoichet, Molly S.