CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.
CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.
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DOI：
10.18632/oncotarget.4763
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发表时间：
2015-09-22
期刊：
影响因子：
--
通讯作者：
Rodriguez-Rodriguez L
中科院分区：
文献类型：
--
作者：
Ravindranath AK;Kaur S;Wernyj RP;Kumaran MN;Miletti-Gonzalez KE;Chan R;Lim E;Madura K;Rodriguez-Rodriguez L
在这里，我们证明，泛素E3连接酶，FBXO 21，靶向多药耐药转运蛋白，ABCB 1，也被称为P-糖蛋白（P-gp），蛋白酶体降解。我们还表明，Ser 291-磷酸化形式的多功能蛋白和干细胞标志物，CD 44，抑制FBXO 21定向降解的P-gp。因此，CD 44增加P-gp介导的耐药性，并代表P-gp阳性细胞中的潜在治疗靶点。
Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp. Thus, CD44 increases P-gp mediated drug resistance and represents a potential therapeutic target in P-gp-positive cells.
影响因子：
2.9
作者：
Hulgan, Todd;Donahue, John P.;Smeaton, Laura;Pu, Minya;Wang, Hongying;Lederman, Michael M.;Smith, Kimberly;Valdez, Hernan;Pilcher, Christopher;Haas, David W.
通讯作者：
Haas, David W.