Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
Anti-Inflamm-Ageing and/or Anti-Age-Related Disease Emerging Treatments: A Historical Alchemy or Revolutionary Effective Procedures?
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DOI：
10.1155/2018/3705389
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发表时间：
2018
影响因子：
4.6
通讯作者：
Balistreri CR
中科院分区：
文献类型：
--
作者：
Balistreri CR
“长生丹”长期以来一直是人类的梦想，是永葆青春、长生不老的虚荣罪孽。如今，由于人口老龄化现象，抗衰老干预措施的研究似乎比以往任何时候都更加重要，以保持老年健康并延缓/或延缓与年龄相关的疾病的发生。实验数据带来了希望，这些数据证明了在动物模型中延缓衰老的可能性。此外，动物延长寿命研究也证明，它不仅可以延长寿命，还可以延缓与年龄相关的疾病的发生。有趣的是，最近的证据有望在人类身上获得相同的效果，并为他们的老年健康带来好处。为了实现这一目标，人们使用了不同的方法，从衰老的药理学靶向、基本生物测定和大数据分析，到最近使用年轻血液、干细胞、细胞、遗传和表观遗传重编程或其他再生医学技术。然而，这些方法中只有一小部分具有在临床应用中进行测试的功能。在这里，将通过证明潜在的好处和局限性来描述新出现的分子、药物和程序。
The “long-life elixir” has long represented for humans a dream, a vanity's sin for remaining young and to long survive. Today, because of ageing population phenomenon, the research of antiageing interventions appears to be more important than ever, for preserving health in old age and retarding/or delaying the onset of age-related diseases. A hope is given by experimental data, which evidence the possibility of retarding ageing in animal models. In addition, it has been also demonstrated in animal life-extending studies not only the possibility of increasing longevity but also the ability to retard the onset of age-related diseases. Interestingly, this recent evidence is leading to promise of obtaining the same effects in humans and resulting in benefits for their health in old ages. In order to achieve this goal, different approaches have been used ranging from pharmacological targeting of ageing, basic biological assays, and big data analysis to the recent use of young blood, stem cells, cellular, genetic, and epigenetic reprogramming, or other techniques of regenerative medicine. However, only a little fraction of these approaches has the features for being tested in clinical applications. Here, new emerging molecules, drugs, and procedures will be described, by evidencing potential benefits and limitations.
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影响因子：
64.8
作者：
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通讯作者：
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影响因子：
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