Anatomy of autophagy: from the beginning to the end

Anatomy of autophagy: from the beginning to the end
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自噬的解剖:从开始到结束

DOI:
10.1007/s00018-017-2657-z
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发表时间:
2018-03
影响因子:
8
通讯作者:
Liu Rong
Liu Rong
中科院分区:
生物学1区
文献类型:
--
作者:
Zhi Xiaoyong;Feng Wenzhi;Rong Yueguang;Liu Rong

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自噬是真核生物中一种高度受调控的过程,用于维持内稳态和应对压力。了解自噬所涉及的调控机制和关键因子,将为疾病相关的发病机制提供重要见解,并且……(原句最后一个单词“p”似乎不完整)
Autophagy is a highly regulated process in eukaryotes to maintain homeostasis and manage stress responses. Understanding the regulatory mechanisms and key players involved in autophagy will provide critical insights into disease-related pathogenesis and potential clinical treatments. In this review, we describe the hallmark events involved in autophagy, from its initiation, to the final destruction of engulfed targets. Furthermore, based on structural and biochemical data, we evaluate the roles of key players in these processes and provide rationale as to how they control autophagic events in a highly ordered manner.
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