Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
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DOI：
10.1002/alz.12150
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Duering M
中科院分区：
文献类型：
--
作者：
Finsterwalder S;Vlegels N;Gesierich B;Araque Caballero MÁ;Weaver NA;Franzmeier N;Georgakis MK;Konieczny MJ;Koek HL;Dominantly Inherited Alzheimer Network (DIAN);Karch CM;Graff-Radford NR;Salloway S;Oh H;Allegri RF;Chhatwal JP;DELCODE study group;Jessen F;Düzel E;Dobisch L;Metzger C;Peters O;Incesoy EI;Priller J;Spruth EJ;Schneider A;Fließbach K;Buerger K;Janowitz D;Teipel SJ;Kilimann I;Laske C;Buchmann M;Heneka MT;Brosseron F;Spottke A;Roy N;Ertl-Wagner B;Scheffler K;Alzheimer's Disease Neuroimaging Initiative (ADNI);Utrecht VCI study group;Seo SW;Kim Y;Na DL;Kim HJ;Jang H;Ewers M;Levin J;Schmidt R;Pasternak O;Dichgans M;Biessels GJ;Duering M
弥散张量成像（DTI）评估的微结构改变是阿尔茨海默病（AD）和小血管疾病（SVD）的关键发现。我们确定了这些条件对扩散变化的贡献。我们研究了6个样本（N=365名参与者），涵盖了AD和SVD的频谱，包括基因定义的样本。我们计算了DTI和自由水成像的扩散量。使用简单线性、多变量随机森林和基于体素的回归来评估AD生物标志物（淀粉样蛋白- β、tau）、SVD成像标志物和扩散测量之间的关联。在所有临床记忆样本的多变量分析中，SVD标记物与扩散测量密切相关，并显示出比AD生物标记物更高的贡献。tau和扩散测量之间的体素分析不显著。在临床记忆患者中，SVD对弥散改变的影响大大超过AD的影响，支持了弥散测量作为SVD标志物的价值。
Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer’s disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. We studied six samples (N=365 participants) covering the spectrum of AD and SVD, including genetically-defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid-beta, tau), SVD imaging markers, and diffusion measures. SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant. In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.
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DOI：
10.1002/alz.12150
发表时间：
2020-11
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Finsterwalder S;Vlegels N;Gesierich B;Araque Caballero MÁ;Weaver NA;Franzmeier N;Georgakis MK;Konieczny MJ;Koek HL;Dominantly Inherited Alzheimer Network (DIAN);Karch CM;Graff-Radford NR;Salloway S;Oh H;Allegri RF;Chhatwal JP;DELCODE study group;Jessen F;Düzel E;Dobisch L;Metzger C;Peters O;Incesoy EI;Priller J;Spruth EJ;Schneider A;Fließbach K;Buerger K;Janowitz D;Teipel SJ;Kilimann I;Laske C;Buchmann M;Heneka MT;Brosseron F;Spottke A;Roy N;Ertl-Wagner B;Scheffler K;Alzheimer's Disease Neuroimaging Initiative (ADNI);Utrecht VCI study group;Seo SW;Kim Y;Na DL;Kim HJ;Jang H;Ewers M;Levin J;Schmidt R;Pasternak O;Dichgans M;Biessels GJ;Duering M
通讯作者：
Duering M
影响因子：
7.1
作者：
Lowe VJ;Curran G;Fang P;Liesinger AM;Josephs KA;Parisi JE;Kantarci K;Boeve BF;Pandey MK;Bruinsma T;Knopman DS;Jones DT;Petrucelli L;Cook CN;Graff-Radford NR;Dickson DW;Petersen RC;Jack CR Jr;Murray ME
通讯作者：
Murray ME
影响因子：
2.6
作者：
Aalten, Pauline;Ramakers, Inez H. G. B.;van der Flier, Wiesje M.
通讯作者：
van der Flier, Wiesje M.
影响因子：
7.1
作者：
McAleese, Kirsty E.;Firbank, Michael;Attems, Johannes
通讯作者：
Attems, Johannes
DOI：
10.1016/j.dadm.2017.01.003
发表时间：
2017-01-01
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
de Wilde, Arno;van Maurik, Ingrid S;van der Flier, Wiesje M
通讯作者：
van der Flier, Wiesje M