Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.
Age of walking and intellectual ability in autism spectrum disorder and other neurodevelopmental disorders: a population-based study.
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自闭症谱系障碍和其他神经发育障碍的步行年龄和智力能力的年龄：基于人群的研究。
DOI：
10.1111/jcpp.13369
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Bishop S
中科院分区：
文献类型：
--
作者：
Havdahl A;Farmer C;Schjølberg S;Øyen AS;Surén P;Reichborn-Kjennerud T;Magnus P;Bresnahan M;Hornig M;Susser E;Lipkin WI;Lord C;Stoltenberg C;Thurm A;Bishop S
延迟行走在智力残疾（ID）中很常见，但当ID与自闭症谱系障碍（ASD）一起发生时可能不太常见。以前的研究由于依赖于临床样本和排除有严重运动缺陷的儿童而受到限制。在基于人群的样本中，研究ASD儿童与其他神经发育障碍（NDD）儿童的行走年龄与智力是否存在差异相关。参与者来自挪威母亲，父亲和儿童队列研究（MoBa）的自闭症出生队列研究。考克斯比例风险回归评估诊断（ASD n=212 vs. NDD n=354）、连续非语言智商及其相互作用是否与连续行走年龄相关。NDD患者的非语言智商与行走年龄之间的关系比ASD患者更强（组x非语言智商相互作用，χ2=13.93，p=0.0002）。这种相互作用的特征是，在观察期间的任何给定时间，NDD组的非语言智商每降低10分，行走开始的可能性降低21%（风险比=0.79，95% CI：0.78-0.85），而ASD组为8%（风险比=0.92，95% CI：0.86-0.98）。在一个基于人群的样本中，与没有其他NDD的儿童相比，晚走与ASD儿童智力低下的相关性较低，这一发现支持了ASD中ID可能由异质性发育途径引起的假设。晚走可能是一个有用的分层变量的病因学研究，重点是ASD和其他NDD。
Delayed walking is common in intellectual disability (ID) but may be less common when ID occurs with autism spectrum disorder (ASD). Previous studies examining this were limited by reliance on clinical samples and exclusion of children with severe motor deficits. To examine in a population-based sample if age of walking is differentially related to intellectual ability in children with ASD versus other neurodevelopmental disorders (NDD). Participants were from the nested Autism Birth Cohort Study of the Norwegian Mother, Father and Child Cohort Study (MoBa). Cox proportional hazards regression assessed if diagnosis (ASD n=212 versus NDD n=354), continuous nonverbal IQ, and their interaction, were associated with continuous age of walking. The relationship between nonverbal IQ and age of walking was stronger for NDD than for ASD (Group x nonverbal IQ interaction, χ2=13.93, p=0.0002). This interaction was characterized by a 21% decrease in the likelihood of walking onset at any given time during the observation period per 10-point decrease in nonverbal IQ (hazard ratio=0.79, 95% CI: 0.78–0.85) in the NDD group compared to 8% (hazard ratio=0.92, 95% CI: 0.86–0.98) in the ASD group. Replicating the finding in a population-based sample that late walking is less strongly related to low intellectual ability in children with ASD than in children without other NDDs supports the hypothesis that ID in ASD may result from heterogeneous developmental pathways. Late walking may be a useful stratification variable in etiological research focused on ASD and other NDDs.
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DOI：
10.1111/j.1469-7610.2007.01762.x
发表时间：
2007-09-01
影响因子：
7.6
作者：
Corsello, Christina;Hus, Vanessa;Lord, Catherine
通讯作者：
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DOI：
10.1111/j.1469-7610.2011.02398.x
发表时间：
2011-07-01
影响因子：
7.6
作者：
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DOI：
10.1073/pnas.1715427115
发表时间：
2018-02-20
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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