Weighing Scale-Based Pulse Transit Time is a Superior Marker of Blood Pressure than Conventional Pulse Arrival Time.
Weighing Scale-Based Pulse Transit Time is a Superior Marker of Blood Pressure than Conventional Pulse Arrival Time.
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DOI：
10.1038/srep39273
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发表时间：
2016-12-15
影响因子：
4.6
通讯作者：
Mukkamala R
中科院分区：
文献类型：
--
作者：
Martin SL;Carek AM;Kim CS;Ashouri H;Inan OT;Hahn JO;Mukkamala R
脉搏传导时间（PTT）被广泛用于无袖带血压（BP）监测。大多数努力已经采用ECG和手指光电体积描记（PPG）波形之间的时间延迟作为PTT的方便替代。然而，这些传统的脉搏到达时间（PAT）测量包括射血前期（PEP）和通过小的肌肉动脉的时间延迟，因此可能是BP的不可靠标记。我们评估了一种浴室称重秤式系统，用于方便地测量心冲击描记术和足部PPG波形-从而通过更大、更有弹性的动脉测量PTT-在其改善个体受试者BP跟踪的能力方面。我们测量了“规模PTT”，传统的PAT和袖带血压在人类的干预措施，增加血压，但改变PEP和平滑肌收缩不同。PTT量表很好地跟踪了舒张压的变化，最佳情况校准后的相关系数为−0.80 ± 0.02（平均值± SE），均方根误差为7.6 ± 0.5 mmHg。常规PAT在跟踪这些变化方面明显较差，相关系数为-0.60 ± 0.04，均方根误差为14.6 ± 1.5 mmHg（p < 0.05）。PTT量表也比传统PAT更好地跟踪收缩压变化，但未达到可接受的水平。随着进一步的发展，PTT量表可能会允许可靠，方便地测量血压。
Pulse transit time (PTT) is being widely pursued for cuff-less blood pressure (BP) monitoring. Most efforts have employed the time delay between ECG and finger photoplethysmography (PPG) waveforms as a convenient surrogate of PTT. However, these conventional pulse arrival time (PAT) measurements include the pre-ejection period (PEP) and the time delay through small, muscular arteries and may thus be an unreliable marker of BP. We assessed a bathroom weighing scale-like system for convenient measurement of ballistocardiography and foot PPG waveforms – and thus PTT through larger, more elastic arteries – in terms of its ability to improve tracking of BP in individual subjects. We measured “scale PTT”, conventional PAT, and cuff BP in humans during interventions that increased BP but changed PEP and smooth muscle contraction differently. Scale PTT tracked the diastolic BP changes well, with correlation coefficient of −0.80 ± 0.02 (mean ± SE) and root-mean-squared-error of 7.6 ± 0.5 mmHg after a best-case calibration. Conventional PAT was significantly inferior in tracking these changes, with correlation coefficient of −0.60 ± 0.04 and root-mean-squared-error of 14.6 ± 1.5 mmHg (p < 0.05). Scale PTT also tracked the systolic BP changes better than conventional PAT but not to an acceptable level. With further development, scale PTT may permit reliable, convenient measurement of BP.
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影响因子：
4.6
作者：
Kim CS;Ober SL;McMurtry MS;Finegan BA;Inan OT;Mukkamala R;Hahn JO
通讯作者：
Hahn JO
影响因子：
2.5
作者：
Gao M;Olivier NB;Mukkamala R
通讯作者：
Mukkamala R
影响因子：
3.7
作者：
Kelsey, Robert M.;Ornduff, Sidney R.;Alpert, Bruce S.
通讯作者：
Alpert, Bruce S.
影响因子：
4.8
作者：
Hines, EA;Brown, GE
通讯作者：
Brown, GE
影响因子：
7.7
作者：
BLAND, JM;ALTMAN, DG
通讯作者：
ALTMAN, DG