The Emergence of Network Activity Patterns in the Somatosensory Cortex - An Early Window to Autism Spectrum Disorders.
The Emergence of Network Activity Patterns in the Somatosensory Cortex - An Early Window to Autism Spectrum Disorders.
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DOI：
10.1016/j.neuroscience.2021.04.005
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发表时间：
2021-07-01
期刊：
影响因子：
3.3
通讯作者：
De Marco García NV
中科院分区：
文献类型：
--
作者：
Iannone AF;De Marco García NV
在哺乳动物物种中，神经群体的模式化活动是发育中的感觉皮层的一个突出特征。长期以来，许多研究都认识到这些模式的多样性，并描述了它们在空间和时间动态方面的差异。在小鼠躯体感觉皮层中，神经元共激活被认为指导感觉地图的形成并为出生后的感觉处理准备皮层。虽然开创性的研究巧妙地利用切片电生理学和单位记录来表征相关活动，但对潜在电路的详细了解仍然知之甚少。最近，在清醒的小鼠幼仔体内钙成像和神经元类型的遗传易处理性增加的进步，允许前所未有的操纵电路组件在选择的发展时间点。这些新的方法已被证明是揭示发育过程中参与相关活动的神经元身份的基础。特别是，最近的研究强调了中间神经元作为细化空间范围和模式化活动的时间进展的关键。在这里，我们讨论如何紧急的同步活动在出生后的第一个星期是由潜在的γ-氨基丁酸（GABA）能贡献者在体感皮层。此外，参与特定的活动模式本身对神经元成熟和持久性的重要性将在最近的文献调查中特别突出。最后，我们强调如何异常的神经元同步性和中断的抑制性中间神经元活动的神经发育障碍，特别是自闭症谱系障碍（ASD）的感觉扰动的基础，强调未来的调查方法，将时空特征的模式化的活动旁边的细胞成分探测无序电路组装的重要性。
Across mammalian species, patterned activity in neural populations is a prominent feature of developing sensory cortices. Numerous studies have long appreciated the diversity of these patterns, characterizing their differences in spatial and temporal dynamics. In the murine somatosensory cortex, neuronal co-activation is thought to guide the formation of sensory maps and prepare the cortex for sensory processing after birth. While pioneering studies deftly utilized slice electrophysiology and unit recordings to characterize correlated activity, a detailed understanding of the underlying circuits remains poorly understood. More recently, advances in in vivo calcium imaging in awake mouse pups and increasing genetic tractability of neuronal types have allowed unprecedented manipulation of circuit components at select developmental timepoints. These novel approaches have proven fundamental in uncovering the identity of neurons engaged in correlated activity during development. In particular, recent studies have highlighted interneurons as key in refining the spatial extent and temporal progression of patterned activity. Here, we discuss how emergent synchronous activity across the first postnatal weeks is shaped by underlying gamma aminobutyric acid (GABA)ergic contributors in the somatosensory cortex. Further, the importance of participation in specific activity patterns per se for neuronal maturation and perdurance will be of particular highlight in this survey of recent literature. Finally, we underscore how aberrant neuronal synchrony and disrupted inhibitory interneuron activity underlie sensory perturbations in neurodevelopmental disorders, particularly Autism Spectrum Disorders (ASDs), emphasizing the importance of future investigative approaches that incorporate the spatiotemporal features of patterned activity alongside the cellular components to probe disordered circuit assembly.
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影响因子：
2.7
作者：
Arakawa, Hiroyuki;Erzurumlu, Reha S.
通讯作者：
Erzurumlu, Reha S.
DOI：
10.1523/jneurosci.3583-12.2012
发表时间：
2012-12-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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影响因子：
46.9
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影响因子：
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通讯作者：
Yuste, Rafael
影响因子：
2.9
作者：
Chowdhury TG;Jimenez JC;Bomar JM;Cruz-Martin A;Cantle JP;Portera-Cailliau C
通讯作者：
Portera-Cailliau C