Role of whiskers in sensorimotor development of C57BL/6 mice.

Role of whiskers in sensorimotor development of C57BL/6 mice.
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晶须在C57BL/6小鼠的感觉运动发展中的作用。

DOI:
10.1016/j.bbr.2015.03.040
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发表时间:
2015
影响因子:
2.7
通讯作者:
Erzurumlu, Reha S.
Erzurumlu, Reha S.
中科院分区:
心理学3区
文献类型:
--
作者:
Arakawa, Hiroyuki;Erzurumlu, Reha S.

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夜间啮齿动物的神秘触毛(胡须)在其感觉运动行为中发挥着重要作用。关于晶须在早期发育过程中的作用的信息相对较少。我们表征了晶须对出生后 C57BL/6 小鼠感觉运动发育的贡献。在出生后第 4 天 (P) 至第 17 天的一系列行为测试中,对完整小鼠和剪掉胡须的小鼠进行了比较,结果表明,即使胡须被剪掉,雄性和雌性幼崽也会产生反射性运动行为。从 P3 开始每天修剪胡须会导致 P17 体重增加减少,并损害胡须感觉运动协调行为,例如从 P4 到 P17 的悬崖回避和同窝幼崽挤作一团,同时促进 P4 的翻正反射和 P12 的抓握反应。由于主动触须要到两周龄才开始,因此新生儿早期的被动触须必须在调节这些行为中发挥作用。在探索行为开始时(P12),剪掉胡须的新生幼崽在遇到笼壁时也会表现出持续的搜索动作,作为感觉运动发育的补偿机制。胡须的自发运动(胡须)与胡须的呼吸颤动不同。它是晶须的对称振动,频率约为 ∼8 Hz,并在 P10 左右开始。在扫描物体表面期间,胡须以约 12 Hz 的较高频率进行定向、成束的运动,即触诊胡须,出现在 P14 处。睁眼前运动体协调的建立伴随着触诊搅拌,这表明在指导探索性运动行为中发挥着重要作用。
The mystacial vibrissae (whiskers) of nocturnal rodents play a major role in their sensorimotor behaviors. Relatively little information exists on the role of whiskers during early development. We characterized the contribution of whiskers to sensorimotor development in postnatal C57BL/6 mice. A comparison between intact and whisker-clipped mice in a battery of behavioral tests from postnatal day (P) 4 to 17 revealed that both male and female pups develop reflexive motor behavior even when the whiskers are clipped. Daily whisker trimming from P3 onwards results in diminished weight gain by P17, and impairment in whisker sensorimotor coordination behaviors, such as cliff avoidance and littermate huddling from P4 through P17, while facilitation of righting reflex at P4 and grasp response at P12. Since active whisker palpation does not start until 2 weeks of age, passive whisker touch during early neonatal stage must play a role in regulating these behaviors. Around the onset of exploratory behaviors (P12) neonatal whisker-clipped pups also display persistent searching movements when they encounter cage walls as a compensatory mechanism of sensorimotor development. Spontaneous whisker motion (whisking) is distinct from respiratory fluttering of whiskers. It is a symmetrical vibration of whiskers at a rate of approximately ∼8 Hz, and begins around P10. Oriented, bundled movements of whiskers at higher frequencies of ∼12 Hz during scanning object surfaces, i.e., palpation whisking, emerges at P14. The establishment of locomotive body coordination before eyes open accompanies palpation whisking, indicating an important role in the guidance of exploratory motor behaviors.
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