Cost-Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis.
Cost-Effectiveness of Diet and Exercise for Overweight and Obese Patients With Knee Osteoarthritis.
复制标题
DOI：
10.1002/acr.23716
复制
发表时间：
2019-07
影响因子：
4.7
通讯作者：
Messier SP
中科院分区：
文献类型：
--
作者：
Losina E;Smith KC;Paltiel AD;Collins JE;Suter LG;Hunter DJ;Katz JN;Messier SP
The Intensive Diet and Exercise for Arthritis (IDEA) trial showed that an intensive diet and exercise (D+E) program led to a mean 10.6 kg weight reduction and 51% pain reduction in knee osteoarthritis (OA) patients. We investigated the cost-effectiveness of adding this D+E program to treatment for overweight and obese (BMI>27 kg/m2) knee OA patients. We used the Osteoarthritis Policy Model to estimate quality-adjusted life-years (QALYs) and lifetime costs for overweight and obese knee OA patients with and without the D+E program. We evaluated cost-effectiveness with the incremental cost-effectiveness ratio (ICER), a ratio of the differences in lifetime cost and QALYs between treatment strategies. We considered three cost-effectiveness thresholds: $50,000/QALY, $100,000/QALY, and $200,000/QALY. Analyses were conducted from healthcare sector and societal perspectives and used a lifetime horizon. Costs and QALYs were discounted at 3% per year. D+E characteristics were derived from the IDEA trial. Deterministic and probabilistic sensitivity analyses (PSA) evaluated parameter uncertainty and the effect of extending the D+E program duration. In the base case, D+E led to 0.054 QALYs gained per person and cost $1,845 from the healthcare sector perspective and $1,624 from the societal perspective. This resulted in ICERs of $34,100/QALY and $30,000/QALY. In the healthcare sector perspective PSA, D+E had a 58% and 100% likelihood of being cost-effective with thresholds of $50,000/QALY and $100,000/QALY, respectively. Adding D+E to usual care for overweight and obese knee OA patients is cost-effective and should be implemented in clinical practice.
登录
查看更多内容
影响因子：
4.2
作者：
DeLemos, Byron P.;Xiang, Jim;Fleming, R. Rosanna B.
通讯作者：
Fleming, R. Rosanna B.
影响因子：
3.6
作者：
Briggs, Andrew H.;Weinstein, Milton C.;Paltiel, A. David
通讯作者：
Paltiel, A. David
影响因子：
168.9
作者：
Cannon, Christopher P.;Curtis, Sean P.;Laine, Loren
通讯作者：
Laine, Loren
影响因子：
27.4
作者：
Bliddal, Henning;Leeds, Anthony R.;Christensen, Robin
通讯作者：
Christensen, Robin
影响因子：
158.5
作者：
Clegg, DO;Reda, DJ;Williams, HJ
通讯作者：
Williams, HJ