White matter changes caused by chronic solvent abuse.
White matter changes caused by chronic solvent abuse.
复制标题
慢性溶剂滥用引起的白质变化。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Toshio Sato
中科院分区：
文献类型：
--
作者：
N. Yamanouchi;S. Okada;K. Kodama;Shinji Hirai;Hiroshi Sekine;A. Murakami;N. Komatsu;T. Sakamoto;Toshio Sato
PURPOSE
To examine the brain damage of solvent abusers in Japan, where pure industrial toluene is frequently abused.
METHODS
Twenty solvent abusers 17 to 33 years of age with 7.2 +/- 4.0 years of abuse were examined with a 1.5-T MR imaging system.
RESULTS
White matter hyperintensities in cerebrum, brain stem, and cerebellum on T2-weighted images were found in seven cases. The extent of white matter change was most clearly shown on proton density-weighted images. The patients with restricted white matter change and intermediate white matter change showed white matter hyperintensities in the brain stem and cerebellum on T2-weighted images, in some cases, with additional hypointensities in the corresponding T1-weighted images. These patients had mainly abused pure toluene. The patients with diffuse white matter change showed obvious brain atrophy, including hippocampal atrophy and thinning of the corpus callosum. These patients had mainly abused lacquer thinner.
CONCLUSION
There are some patients with restricted but severe enough change to cause the neurologic symptoms in specific regions, such as the brain stem and/or cerebellum, before the brain atrophy becomes apparent. This suggests that the restricted white matter change represents not only an early change of diffuse white matter change, but at least in some cases also represents a qualitatively different change than that of diffuse white matter change. We suggest that pure toluene has a possible relation to this qualitative difference.
甲苯滥用：T2 加权 MR 图像上基底神经节低信号的物理基础。
影响因子：
19.7
作者：
Unger,E;Alexander,A;Fritz,T;Rosenberg,N;Dreisbach,J
通讯作者：
Dreisbach,J