Exposures, mechanisms, and impacts of endocrine-active flame retardants.
Exposures, mechanisms, and impacts of endocrine-active flame retardants.
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DOI：
10.1016/j.coph.2014.09.018
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发表时间：
2014-12
影响因子：
4
通讯作者：
Stapleton, Heather M.
中科院分区：
文献类型：
--
作者：
Dishaw, Laura V.;Macaulay, Laura J.;Roberts, Simon C.;Stapleton, Heather M.
本文综述了两种目前使用的添加剂阻燃剂（FRs），三（1,3-二氯异丙基）磷酸盐（TDCPP）和Firemaster®550 (fm550)，以及最近逐步淘汰的多溴联苯醚（PBDEs）的内分泌和神经发育影响，所有这些阻燃剂过去或现在都用于聚氨酯泡沫应用。在消费品中使用这些化学物质已导致室内环境中的广泛接触。多溴二苯醚及其羟基化代谢物似乎主要针对甲状腺系统，可能是由于它们与内源性甲状腺激素的结构相似性。相比之下，人们对TDCPP和FM550的毒性知之甚少。然而，最近的体外和体内研究表明，两者都应被视为内分泌干扰物，因为研究表明TDCPP暴露与循环激素水平的变化有关，fm550暴露与脂肪生成和成骨途径的变化有关。
This review summarizes the endocrine and neurodevelopmental effects of two current-use additive flame retardants (FRs), tris (1,3-dichloro-isopropyl) phosphate (TDCPP) and Firemaster® 550 (FM 550), and the recently phased-out polybrominated diphenyl ethers (PBDEs), all of which were historically or are currently used in polyurethane foam applications. Use of these chemicals in consumer products has led to widespread exposure in indoor environments. PBDEs and their hydroxylated metabolites appear to primarily target the thyroid system, likely due to their structural similarity to endogenous thyroid hormones. In contrast, much less is known about the toxicity of TDCPP and FM550. However, recent in vitro and in vivo studies suggest that both should be considered endocrine disruptors as studies have linked TDCPP exposure with changes in circulating hormone levels, and FM 550 exposure with changes in adipogenic and osteogenic pathways.
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影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
通讯作者：
Perera F
影响因子：
3.8
作者：
Dishaw LV;Powers CM;Ryde IT;Roberts SC;Seidler FJ;Slotkin TA;Stapleton HM
通讯作者：
Stapleton HM
影响因子：
10.4
作者：
Ibhazehiebo K;Iwasaki T;Kimura-Kuroda J;Miyazaki W;Shimokawa N;Koibuchi N
通讯作者：
Koibuchi N
影响因子：
13.6
作者：
Kajiwara, Natsuko;Noma, Yukio;Takigami, Hidetaka
通讯作者：
Takigami, Hidetaka
影响因子：
10.4
作者：
Dingemans MM;van den Berg M;Westerink RH
通讯作者：
Westerink RH