Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis.
Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis.
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DOI：
10.3390/biomedicines8110464
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发表时间：
2020-10-31
期刊：
影响因子：
4.7
通讯作者：
Arias-Santiago S
中科院分区：
文献类型：
--
作者：
Sanabria-de la Torre R;Fernández-González A;Quiñones-Vico MI;Montero-Vilchez T;Arias-Santiago S
本综述旨在更新生物工程人造皮肤替代品 (BASS) 应用。最初，它们的创建是为了尝试替代天然皮肤移植移植。如今，这些体外模型的应用领域不断增加和拓宽，成为重要的研究工具。这项研究的重点是设计体外 BASS 的能力，该能力已被证明适合在化妆品和药理学行业开发新产品。允许更深入地研究皮肤病，并分析环境压力因素引起的影响。 BASS取代动物实验的重要性也被强调。此外，还分析了 OECD（经济合作与发展组织）批准的 BASS 验证参数。本报告概述了适用于皮肤研究的皮肤模型及其设计方法。最后，讨论了当前可用的 BASS 满足疾病建模和药物筛选需求的潜力和局限性。
This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed.
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影响因子：
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